Next Article in Journal
Facile Synthesis of SrCO3-Sr(OH)2/PPy Nanocomposite with Enhanced Photocatalytic Activity under Visible Light
Previous Article in Journal
Poly-γ-Glutamic Acid: Biodegradable Polymer for Potential Protection of Beneficial Viruses
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Materials 2016, 9(1), 29; doi:10.3390/ma9010029

Triggered Release from Thermoresponsive Polymersomes with Superparamagnetic Membranes

1
Institute for Biologically Inspired Materials, Department of Nanobiotechnology, University of Natural Resources and Life Sciences, Vienna, Muthgasse 11, Vienna 1190, Austria
2
School of Materials Science and Engineering, Centre for Biomimetic Sensor Science, Nanyang Technological University, 50 Nanyang Drive, 637553 Singapore
*
Author to whom correspondence should be addressed.
Academic Editor: Beatriz Noheda
Received: 29 October 2015 / Revised: 14 December 2015 / Accepted: 28 December 2015 / Published: 6 January 2016
(This article belongs to the Section Advanced Composites)
View Full-Text   |   Download PDF [1857 KB, uploaded 6 January 2016]   |  

Abstract

Magnetic polymersomes were prepared by self-assembly of the amphiphilic block copolymer poly(isoprene-b-N-isopropylacrylamide) with monodisperse hydrophobic superparamagnetic iron oxide nanoparticles (SPION). The specifically designed thermoresponsive block copolymer allowed for efficient incorporation of the hydrophobic nanoparticles in the membrane core and encapsulation of the water soluble dye calcein in the lumen of the vesicles. Magnetic heating of the embedded SPIONs led to increased bilayer permeability through dehydration of the thermoresponsive PNIPAM block. The entrapped calcein could therefore be released in controlled doses solely through exposure to pulses of an alternating magnetic field. This hybrid SPION-polymersome system demonstrates a possible direction for release applications that merges rational polymersome design with addressed external magnetic field-triggered release through embedded nanomaterials. View Full-Text
Keywords: superparamagnetic iron oxide nanoparticle; thermoresponsive polymer; magneto-polymersome; magneto-thermal release; calcein assay superparamagnetic iron oxide nanoparticle; thermoresponsive polymer; magneto-polymersome; magneto-thermal release; calcein assay
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bixner, O.; Kurzhals, S.; Virk, M.; Reimhult, E. Triggered Release from Thermoresponsive Polymersomes with Superparamagnetic Membranes. Materials 2016, 9, 29.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top