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Materials 2015, 8(9), 6401-6418; doi:10.3390/ma8095309

Development of Chitosan/Bacterial Cellulose Composite Films Containing Nanodiamonds as a Potential Flexible Platform for Wound Dressing

1
Department of Materials Science and Engineering, Sharif University of Technology, PO Box 11155-9161, Tehran, Iran
2
Fundacion Andaltec I+D+i, Poligono industrial Cañada de la Fuente, 23600 Martos, Jaen, Spain
3
Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran
4
Institute for Nanoscience and Nanotechnology, Sharif University of Technology, PO Box 11365-9466, Tehran, Iran
*
Author to whom correspondence should be addressed.
Academic Editor: Armando Silvestre
Received: 6 July 2015 / Revised: 29 August 2015 / Accepted: 3 September 2015 / Published: 18 September 2015
(This article belongs to the Special Issue Biobased Nanocomposite Functional Materials)
View Full-Text   |   Download PDF [6286 KB, uploaded 18 September 2015]   |  

Abstract

Chitosan/bacterial cellulose composite films containing diamond nanoparticles (NDs) with potential application as wound dressing are introduced. Microstructural studies show that NDs are uniformly dispersed in the matrix, although slight agglomeration at concentrations above 2 wt % is seen. Fourier transform infrared spectroscopy reveals formation of hydrogen bonds between NDs and the polymer matrix. X-ray diffraction analysis indicates reduced crystallinity of the polymer matrix in the presence of NDs. Approximately 3.5-fold increase in the elastic modulus of the composite film is obtained by the addition of 2 wt % NDs. The results of colorimetric analysis show that the composite films are transparent but turn to gray-like and semitransparent at high ND concentrations. Additionally, a decrease in highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) gap is also seen, which results in a red shift and higher absorption intensity towards the visible region. Mitochondrial activity assay using L929 fibroblast cells shows that the nanocomposite films are biocompatible (>90%) after 24 h incubation. Multiple lamellapodia and cell-cell interaction are shown. The results suggest that the developed films can potentially be used as a flexible platform for wound dressing. View Full-Text
Keywords: nanocomposite; nanodiamond; chitosan; bacterial cellulose; wound dressing nanocomposite; nanodiamond; chitosan; bacterial cellulose; wound dressing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ostadhossein, F.; Mahmoudi, N.; Morales-Cid, G.; Tamjid, E.; Navas-Martos, F.J.; Soriano-Cuadrado, B.; Paniza, J.M.L.; Simchi, A. Development of Chitosan/Bacterial Cellulose Composite Films Containing Nanodiamonds as a Potential Flexible Platform for Wound Dressing. Materials 2015, 8, 6401-6418.

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