Sustained Administration of Hormones Exploiting Nanoconfined Diffusion through Nanochannel Membranes
Abstract
:1. Introduction
2. Results and Discussion
2.1. Levothyroxine
Properties | Osteocalcin | Levothyroxine | Testosterone |
---|---|---|---|
Mass (Da) | 5929 | 777 | 288 |
Net Charge (pH 7.4) | −6 | −0.5 | 0 |
Radius (Å) | 10 | 4.3 | 4.1 |
LogD (PH 7.4) | ~−6 | 1.76 | 3.16 |
2.2. Osteocalcin
2.3. Testosterone
3. Materials and Methods
3.1. Nanochannel Membrane Fabrication
3.2. Levothyroxine Release
3.3. Osteocalcin Release
3.4. Testosterone Release
3.5. Computational Methods
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Geninatti, T.; Hood, R.L.; Bruno, G.; Jain, P.; Nicolov, E.; Ziemys, A.; Grattoni, A. Sustained Administration of Hormones Exploiting Nanoconfined Diffusion through Nanochannel Membranes. Materials 2015, 8, 5276-5288. https://doi.org/10.3390/ma8085241
Geninatti T, Hood RL, Bruno G, Jain P, Nicolov E, Ziemys A, Grattoni A. Sustained Administration of Hormones Exploiting Nanoconfined Diffusion through Nanochannel Membranes. Materials. 2015; 8(8):5276-5288. https://doi.org/10.3390/ma8085241
Chicago/Turabian StyleGeninatti, Thomas, R. Lyle Hood, Giacomo Bruno, Priya Jain, Eugenia Nicolov, Arturas Ziemys, and Alessandro Grattoni. 2015. "Sustained Administration of Hormones Exploiting Nanoconfined Diffusion through Nanochannel Membranes" Materials 8, no. 8: 5276-5288. https://doi.org/10.3390/ma8085241