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Materials 2015, 8(8), 5276-5288; doi:10.3390/ma8085241

Sustained Administration of Hormones Exploiting Nanoconfined Diffusion through Nanochannel Membranes

1
Nanomedicine Department, Houston Methodist Research Institute, Houston, TX 77030, USA
2
College of Materials Science and Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
3
Electronics and Telecommunications Department, Politecnico di Torino, Turin 10024, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Sergey Vasenkov
Received: 1 May 2015 / Revised: 5 August 2015 / Accepted: 5 August 2015 / Published: 13 August 2015
(This article belongs to the Special Issue Diffusion under Confinement in Nanopores)
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Abstract

Implantable devices may provide a superior means for hormone delivery through maintaining serum levels within target therapeutic windows. Zero-order administration has been shown to reach an equilibrium with metabolic clearance, resulting in a constant serum concentration and bioavailability of released hormones. By exploiting surface-to-molecule interaction within nanochannel membranes, it is possible to achieve a long-term, constant diffusive release of agents from implantable reservoirs. In this study, we sought to demonstrate the controlled release of model hormones from a novel nanochannel system. We investigated the delivery of hormones through our nanochannel membrane over a period of 40 days. Levothyroxine, osteocalcin and testosterone were selected as representative hormones based on their different molecular properties and structures. The release mechanisms and transport behaviors of these hormones within 3, 5 and 40 nm channels were characterized. Results further supported the suitability of the nanochannels for sustained administration from implantable platforms. View Full-Text
Keywords: nanochannel membrane; nanoconfinement; nanoscale diffusion; drug delivery; hormone replacement nanochannel membrane; nanoconfinement; nanoscale diffusion; drug delivery; hormone replacement
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Geninatti, T.; Hood, R.L.; Bruno, G.; Jain, P.; Nicolov, E.; Ziemys, A.; Grattoni, A. Sustained Administration of Hormones Exploiting Nanoconfined Diffusion through Nanochannel Membranes. Materials 2015, 8, 5276-5288.

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