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Materials 2015, 8(6), 3508-3518; doi:10.3390/ma8063508

Highly Stretchable, Biocompatible, Striated Substrate Made from Fugitive Glue

1
Department of Physics, Wake Forest University, 7507 Reynolda Station, Winston-Salem, NC 27109, USA
2
Department of Biochemistry and Molecular Biology, School of Medicine Wake Forest University, Winston-Salem, NC 27157, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Amir A. Zadpoor
Received: 21 March 2015 / Accepted: 8 June 2015 / Published: 15 June 2015
(This article belongs to the Special Issue Mechanics of Biomaterials)
View Full-Text   |   Download PDF [1600 KB, uploaded 15 June 2015]   |  

Abstract

We developed a novel substrate made from fugitive glue (styrenic block copolymer) that can be used to analyze the effects of large strains on biological samples. The substrate has the following attributes: (1) It is easy to make from inexpensive components; (2) It is transparent and can be used in optical microscopy; (3) It is extremely stretchable as it can be stretched up to 700% strain; (4) It can be micro-molded, for example we created micro-ridges that are 6 μm high and 13 μm wide; (5) It is adhesive to biological fibers (we tested fibrin fibers), and can be used to uniformly stretch those fibers; (6) It is non-toxic to cells (we tested human mammary epithelial cells); (7) It can tolerate various salt concentrations up to 5 M NaCl and low (pH 0) and high (pH 14) pH values. Stretching of this extraordinary stretchable substrate is relatively uniform and thus, can be used to test multiple cells or fibers in parallel under the same conditions. View Full-Text
Keywords: biocompatible substrate; fugitive glue; credit card glue; styrenic block copolymer; stretchable; transparent; fibrin fibers; human mammary epithelial cells biocompatible substrate; fugitive glue; credit card glue; styrenic block copolymer; stretchable; transparent; fibrin fibers; human mammary epithelial cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Li, W.; Lucioni, T.; Guo, X.; Smelser, A.; Guthold, M. Highly Stretchable, Biocompatible, Striated Substrate Made from Fugitive Glue. Materials 2015, 8, 3508-3518.

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