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Materials 2015, 8(2), 379-391; doi:10.3390/ma8020379

Preparation of pH Sensitive Pluronic-Docetaxel Conjugate Micelles to Balance the Stability and Controlled Release Issues

School of Pharmaceutical Science, Shandong University, 44 Wenhua Xi Road, Ji'nan 250012, Shandong, China
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Author to whom correspondence should be addressed.
Academic Editor: Loo Say Chye Joachim
Received: 17 November 2014 / Accepted: 13 January 2015 / Published: 23 January 2015
(This article belongs to the Special Issue Materials for Drug Delivery)
View Full-Text   |   Download PDF [928 KB, uploaded 23 January 2015]   |  

Abstract

A novel polymer-drug conjugate was prepared by the chemical reaction between the copolymer Pluronic P123 and the docetaxel via a pH sensitive hydrazone bond. These pluronic P123-docetaxel (DTX) conjugates (P123-DTX) could form the stable drug-loaded materials that can self-assemble into the defined nano-micelles in aqueous solution because of their obvious amphiphilic property and low critical micelle concentration. The spherical morphology and particle size of the prepared nano-micelles were characterized by transmission electron microscopy and dynamic light scattering, respectively. Moreover, after the introduction of pH sensitive hydrazone bond, P123-DTX micelle showed a pH dependent drug release behavior. At pH 5.0 (in 48 h), the cumulative release amount of DTX were ~84.9%, which is about six times higher than that at pH 7.4. The prepared novel p123-DTX conjugates may offer a great benefit for drug delivery and controlling the drug release. View Full-Text
Keywords: docetaxel; conjugates; nano-micelles; stability; pH controlled release docetaxel; conjugates; nano-micelles; stability; pH controlled release
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Liang, Y.; Su, Z.; Yao, Y.; Zhang, N. Preparation of pH Sensitive Pluronic-Docetaxel Conjugate Micelles to Balance the Stability and Controlled Release Issues. Materials 2015, 8, 379-391.

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