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Materials 2015, 8(11), 7604-7614; doi:10.3390/ma8115404

Patchwork Coating of Fragmented Ultra-Thin Films and Their Biomedical Applications in Burn Therapy and Antithrombotic Coating

1
Department of Applied Chemistry, School of Engineering, Tokai University, 4-1-1 Kitakaname, Hiratsuka, Kanagawa 259-1292, Japan
2
European Biomedical Science Institute, Organization for Regional and Inter-Regional Studies, Waseda University, 513 Wasedatsurumakicho, Shinjuku, Tokyo 162-0041, Japan
3
Department of Life Science and Medical Bioscience, School of Advanced Science and Engineering, Waseda University, TWIns, 2-2 Wakamatsucho, Shinjuku, Tokyo 162-8480, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Aldo R. Boccaccini
Received: 25 August 2015 / Accepted: 3 November 2015 / Published: 11 November 2015
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Abstract

We have proposed free-standing centimeter-sized ultra-thin films (nanosheets) for biomedical applications. Such nanosheets exhibit unique properties such as transparency, flexibility, and good adhesiveness. However, they are only easily adhered to broad and flat surfaces due to their dimensions. To this end, we recently proposed an innovative nanomaterial: the nanosheets fragmented into submillimeter-size pieces. Intriguingly, such fragmented nanosheets could be adhered to uneven and irregular surfaces in addition to flat surfaces in a spread-out “patchwork” manner. We herein review the fabrication procedure and characterization of fragmented nanosheets composed of biodegradable polyesters and thermostable bio-friendly polymers, and their biomedical applications in burn therapy and antithrombotic coating using a “patchwork coating”. View Full-Text
Keywords: ultra-thin films (nanosheets); fragmentation; patchwork; biocompatibility; biodegradability; poly(l-lactic acid); phosphorylcholine ultra-thin films (nanosheets); fragmentation; patchwork; biocompatibility; biodegradability; poly(l-lactic acid); phosphorylcholine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Okamura, Y.; Nagase, Y.; Takeoka, S. Patchwork Coating of Fragmented Ultra-Thin Films and Their Biomedical Applications in Burn Therapy and Antithrombotic Coating. Materials 2015, 8, 7604-7614.

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