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Correction published on 1 December 2015, see Materials 2015, 8(12), 8147.

Open AccessArticle
Materials 2015, 8(10), 6685-6696; doi:10.3390/ma8105332

Preparation, Characterization and Evaluation of α-Tocopherol Succinate-Modified Dextran Micelles as Potential Drug Carriers

1
School of Pharmacy and Life Sciences, Jiujiang University, 320 Xunyang East Road, Jiujiang 332000, China
2
School of Chemical and Biological Engneering, Yichun University, 576 Xuefu Road, Yichun 336000, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Jung Kwon (John) Oh
Received: 18 August 2015 / Revised: 13 September 2015 / Accepted: 17 September 2015 / Published: 28 September 2015
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [3896 KB, uploaded 7 December 2015]   |  

Abstract

In the present study, α-tocopherol succinate (TOS) conjugated dextran (Dex-TOS) was synthesized and characterized by fourier transform infrared (FT-IR) spectroscopy, 1H nuclear magnetic resonance (1H NMR), dynamic light scattering (DLS) and fluorescence spectroscopy. Dex-TOS could form nanoscaled micelles in aqueous medium. The critical micelle concentration (CMC) is 0.0034 mg/mL. Doxorubicin (Dox) was selected as a model drug. Dox-loaded Dex-TOS (Dex-TOS/Dox) micelles were prepared by a dialysis method. The size of Dex-TOS/Dox micelles increased from 295 to 325 nm with the Dox-loading content increasing from 4.21% to 8.12%. The Dex-TOS/Dox micelles were almost spherical in shape, as determined by transmission electron microscopy (TEM). In vitro release demonstrated that Dox release from the micelles was in a sustained manner for up to 96 h. The cellular uptake of Dex-TOS/Dox micelles in human nasopharyngeal epidermoid carcinoma (KB) cells is an endocytic process determined by confocal laser scanning microscopy (CLSM). Moreover, Dex-TOS/Dox micelles exhibited comparable cytotoxicity in contrast with doxorubicin hydrochloride. These results suggested that Dex-TOS micelles could be a promising carrier for drug delivery. View Full-Text
Keywords: dextran; α-tocopherol succinate; polymeric micelles; doxorubicin; drug carrier dextran; α-tocopherol succinate; polymeric micelles; doxorubicin; drug carrier
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yu, J.; Zhou, Y.; Chen, W.; Ren, J.; Zhang, L.; Lu, L.; Luo, G.; Huang, H. Preparation, Characterization and Evaluation of α-Tocopherol Succinate-Modified Dextran Micelles as Potential Drug Carriers. Materials 2015, 8, 6685-6696.

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