Next Article in Journal
Previous Article in Journal
Materials 2014, 7(3), 2210-2228; doi:10.3390/ma7032210
Article

Cathodic Polarization Coats Titanium Based Implant Materials with Enamel Matrix Derivate (EMD)

1,2
, 1,2
, 3
, 4
, 1,3
, 1
, 1,*  and 1
Received: 29 January 2014; in revised form: 5 March 2014 / Accepted: 10 March 2014 / Published: 14 March 2014
(This article belongs to the Section Biomaterials)
View Full-Text   |   Download PDF [912 KB, uploaded 14 March 2014]
Abstract: The idea of a bioactive surface coating that enhances bone healing and bone growth is a strong focus of on-going research for bone implant materials. Enamel matrix derivate (EMD) is well documented to support bone regeneration and activates growth of mesenchymal tissues. Thus, it is a prime candidate for coating of existing implant surfaces. The aim of this study was to show that cathodic polarization can be used for coating commercially available implant surfaces with an immobilized but functional and bio-available surface layer of EMD. After coating, XPS revealed EMD-related bindings on the surface while SIMS showed incorporation of EMD into the surface. The hydride layer of the original surface could be activated for coating in an integrated one-step process that did not require any pre-treatment of the surface. SEM images showed nano-spheres and nano-rods on coated surfaces that were EMD-related. Moreover, the surface roughness remained unchanged after coating, as it was shown by optical profilometry. The mass peaks observed in the matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MS) analysis confirmed the integrity of EMD after coating. Assessment of the bioavailability suggested that the modified surfaces were active for osteoblast like MC3M3-E1 cells in showing enhanced Coll-1 gene expression and ALP activity.
Keywords: bioactive coating; coating technique; enamel matrix derivate; EMD; titanium; titanium-zirconium; surface modification bioactive coating; coating technique; enamel matrix derivate; EMD; titanium; titanium-zirconium; surface modification
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Frank, M.J.; Walter, M.S.; Rubert, M.; Thiede, B.; Monjo, M.; Reseland, J.E.; Haugen, H.J.; Lyngstadaas, S.P. Cathodic Polarization Coats Titanium Based Implant Materials with Enamel Matrix Derivate (EMD). Materials 2014, 7, 2210-2228.

AMA Style

Frank MJ, Walter MS, Rubert M, Thiede B, Monjo M, Reseland JE, Haugen HJ, Lyngstadaas SP. Cathodic Polarization Coats Titanium Based Implant Materials with Enamel Matrix Derivate (EMD). Materials. 2014; 7(3):2210-2228.

Chicago/Turabian Style

Frank, Matthias J.; Walter, Martin S.; Rubert, Marina; Thiede, Bernd; Monjo, Marta; Reseland, Janne E.; Haugen, Håvard J.; Lyngstadaas, Ståle P. 2014. "Cathodic Polarization Coats Titanium Based Implant Materials with Enamel Matrix Derivate (EMD)." Materials 7, no. 3: 2210-2228.


Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert