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Materials 2014, 7(2), 653-661; doi:10.3390/ma7020653
Article

Preparation of Multifunctional Fe@Au Core-Shell Nanoparticles with Surface Grafting as a Potential Treatment for Magnetic Hyperthermia

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Received: 18 November 2013; in revised form: 26 November 2013 / Accepted: 16 January 2014 / Published: 24 January 2014
(This article belongs to the Section Biomaterials)
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Abstract: Iron core gold shell nanoparticles grafted with Methotrexate (MTX) and indocyanine green (ICG) were synthesized for the first time in this study, and preliminarily evaluated for their potential in magnetic hyperthermia treatment. The core-shell Fe@Au nanoparticles were prepared via the microemulsion process and then grafted with MTX and ICG using hydrolyzed poly(styrene-alt-maleic acid) (PSMA) to obtain core-shell Fe@Au-PSMA-ICG/MTX nanoparticles. MTX is an anti-cancer therapeutic, and ICG is a fluorescent dye. XRD, TEM, FTIR and UV-Vis spectrometry were performed to characterize the nanoparticles. The data indicated that the average size of the nanoparticles was 6.4 ± 09 nm and that the Au coating protected the Fe core from oxidation. MTX and ICG were successfully grafted onto the surface of the nanoparticles. Under exposure to high frequency induction waves, the superparamagnetic nanoparticles elevated the temperature of a solution in a few minutes, which suggested the potential for an application in magnetic hyperthermia treatment. The in vitro studies verified that the nanoparticles were biocompatible; nonetheless, the Fe@Au-PSMA-ICG/MTX nanoparticles killed cancer cells (Hep-G2) via the magnetic hyperthermia mechanism and the release of MTX.
Keywords: methotrexate; indocyanine green; core-shell Fe@Au-PSMA-ICG/MTX nanoparticles; magnetic hyperthermia treatment; in vitro studies methotrexate; indocyanine green; core-shell Fe@Au-PSMA-ICG/MTX nanoparticles; magnetic hyperthermia treatment; in vitro studies
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Chung, R.-J.; Shih, H.-T. Preparation of Multifunctional Fe@Au Core-Shell Nanoparticles with Surface Grafting as a Potential Treatment for Magnetic Hyperthermia. Materials 2014, 7, 653-661.

AMA Style

Chung R-J, Shih H-T. Preparation of Multifunctional Fe@Au Core-Shell Nanoparticles with Surface Grafting as a Potential Treatment for Magnetic Hyperthermia. Materials. 2014; 7(2):653-661.

Chicago/Turabian Style

Chung, Ren-Jei; Shih, Hui-Ting. 2014. "Preparation of Multifunctional Fe@Au Core-Shell Nanoparticles with Surface Grafting as a Potential Treatment for Magnetic Hyperthermia." Materials 7, no. 2: 653-661.


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