Sustained Release of Hydrophilic l-ascorbic acid 2-phosphate Magnesium from Electrospun Polycaprolactone Scaffold—A Study across Blend, Coaxial, and Emulsion Electrospinning Techniques
Abstract
:1. Introduction
2. Results and Discussion
2.1. ASP–PCL Scaffolds Prepared by Coaxial and Emulsion Electrospinnings
Scaffolds (Electrospun methods) | Loading efficiency (%) | Initial release within day 1 (%) | Total release within 14 days (%) | Young’s Modular (MP) | |
---|---|---|---|---|---|
Coaxial | 92.6 ± 3.4 | 86.1 ± 15.3 | 99.8 | - | |
Emulsion | 46.1 ± 7.2 | 42.5 ± 2.7 | 70.2 | 8.7 | |
Blend | DCM–DMF = 7:3 | 78.5 ± 9.7 | 7.8 ± 0.3 | 15.2 | 9.7 |
DCM–MeOH = 8:2 | 73.7 ± 1.5 | 26.9 ± 0.9 | 50.2 | 6.7 | |
DCM–MeOH = 7:3 | 80.3 ± 4.5 | 22.0 ± 1.9 | 59.1 | 6.7 | |
DCM–MeOH = 6:4 | 81.0 ± 11.2 | 23.2 ± 4.6 | 55.4 | 6.4 |
2.2. ASP–PCL Scaffolds Prepared by Blend Electrospinning by Using Binary Solvent Systems
2.3. Mechanical Properties of ASP–PCL Scaffolds
3. Experimental Section
3.1. Scaffold Preparation
3.1.1. Preparation of ASP–PCL Solutions for Coaxial, Emulsion and Blend Electrospinning
3.1.2. Electrospinning of ASP–PCL Scaffolds
3.2. Scaffold Characterization
3.2.1. Morphology Assessment
3.2.2. ASP Encapsulation Efficiency
3.2.3. ASP Release Study
3.2.4. Mechanical Properties
3.3. Statistical Analysis
4. Conclusions
Supplementary Materials
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Zhao, X.; Lui, Y.S.; Toh, P.W.J.; Loo, S.C.J. Sustained Release of Hydrophilic l-ascorbic acid 2-phosphate Magnesium from Electrospun Polycaprolactone Scaffold—A Study across Blend, Coaxial, and Emulsion Electrospinning Techniques. Materials 2014, 7, 7398-7408. https://doi.org/10.3390/ma7117398
Zhao X, Lui YS, Toh PWJ, Loo SCJ. Sustained Release of Hydrophilic l-ascorbic acid 2-phosphate Magnesium from Electrospun Polycaprolactone Scaffold—A Study across Blend, Coaxial, and Emulsion Electrospinning Techniques. Materials. 2014; 7(11):7398-7408. https://doi.org/10.3390/ma7117398
Chicago/Turabian StyleZhao, Xinxin, Yuan Siang Lui, Pei Wen Jessica Toh, and Say Chye Joachim Loo. 2014. "Sustained Release of Hydrophilic l-ascorbic acid 2-phosphate Magnesium from Electrospun Polycaprolactone Scaffold—A Study across Blend, Coaxial, and Emulsion Electrospinning Techniques" Materials 7, no. 11: 7398-7408. https://doi.org/10.3390/ma7117398