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Materials 2014, 7(11), 7398-7408; doi:10.3390/ma7117398

Sustained Release of Hydrophilic l-ascorbic acid 2-phosphate Magnesium from Electrospun Polycaprolactone Scaffold—A Study across Blend, Coaxial, and Emulsion Electrospinning Techniques

1
School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798 Singapore
2
Singapore Centre on Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University 60 Nanyang Drive, 637551 Singapore
*
Author to whom correspondence should be addressed.
Received: 5 September 2014 / Revised: 28 October 2014 / Accepted: 6 November 2014 / Published: 17 November 2014
(This article belongs to the Special Issue Materials for Drug Delivery)
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Abstract

The purpose of this study was to achieve a sustained release of hydrophilic l-ascorbic acid 2-phosphate magnesium (ASP) from electrospun polycaprolactone (PCL) scaffolds, so as to promote the osteogenic differentiation of stem cells for bone tissue engineering (TE). ASP was loaded and electrospun together with PCL via three electrospinning techniques, i.e., coaxial, emulsion, and blend electrospinning. For blend electrospinning, binary solvent systems of dichloromethane–methanol (DCM–MeOH) and dichloromethane–dimethylformamide (DCM–DMF) were used to achieve the desired ASP release through the effect of solvent polarity and volatility. The scaffold prepared via a blend electrospinning technique with a binary solvent system of DCM–MeOH at a 7:3 ratio demonstrated a desirable, sustained ASP release profile for as long as two weeks, with minimal burst release. However, an undesirable burst release (~100%) was observed within the first 24 h for scaffolds prepared by coaxial electrospinning. Scaffolds prepared by emulsion electrospinning displayed poorer mechanical properties. Sustained releasing blend electrospun scaffold could be a good potential candidate as an ASP-eluting scaffold for bone tissue engineering. View Full-Text
Keywords: electrospinning; ascorbate-2-phosphate; release electrospinning; ascorbate-2-phosphate; release
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zhao, X.; Lui, Y.S.; Toh, P.W.J.; Loo, S.C.J. Sustained Release of Hydrophilic l-ascorbic acid 2-phosphate Magnesium from Electrospun Polycaprolactone Scaffold—A Study across Blend, Coaxial, and Emulsion Electrospinning Techniques. Materials 2014, 7, 7398-7408.

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