Next Article in Journal
Vibration Modes at Terahertz and Infrared Frequencies of Ionic Liquids Consisting of an Imidazolium Cation and a Halogen Anion
Next Article in Special Issue
Cholesterol-Enhanced Polylactide-Based Stereocomplex Micelle for Effective Delivery of Doxorubicin
Previous Article in Journal
Ceo2 Based Catalysts for the Treatment of Propylene in Motorcycle’s Exhaust Gases
Previous Article in Special Issue
A Novel Exploration of a Combination of Gambogic Acid with TiO2 Nanofibers: The Photodynamic Effect for HepG2 Cell Proliferation
Article Menu

Export Article

Open AccessCommunication
Materials 2014, 7(11), 7398-7408; doi:10.3390/ma7117398

Sustained Release of Hydrophilic l-ascorbic acid 2-phosphate Magnesium from Electrospun Polycaprolactone Scaffold—A Study across Blend, Coaxial, and Emulsion Electrospinning Techniques

School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798 Singapore
Singapore Centre on Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University 60 Nanyang Drive, 637551 Singapore
Author to whom correspondence should be addressed.
Received: 5 September 2014 / Revised: 28 October 2014 / Accepted: 6 November 2014 / Published: 17 November 2014
(This article belongs to the Special Issue Materials for Drug Delivery)
View Full-Text   |   Download PDF [782 KB, uploaded 17 November 2014]   |  


The purpose of this study was to achieve a sustained release of hydrophilic l-ascorbic acid 2-phosphate magnesium (ASP) from electrospun polycaprolactone (PCL) scaffolds, so as to promote the osteogenic differentiation of stem cells for bone tissue engineering (TE). ASP was loaded and electrospun together with PCL via three electrospinning techniques, i.e., coaxial, emulsion, and blend electrospinning. For blend electrospinning, binary solvent systems of dichloromethane–methanol (DCM–MeOH) and dichloromethane–dimethylformamide (DCM–DMF) were used to achieve the desired ASP release through the effect of solvent polarity and volatility. The scaffold prepared via a blend electrospinning technique with a binary solvent system of DCM–MeOH at a 7:3 ratio demonstrated a desirable, sustained ASP release profile for as long as two weeks, with minimal burst release. However, an undesirable burst release (~100%) was observed within the first 24 h for scaffolds prepared by coaxial electrospinning. Scaffolds prepared by emulsion electrospinning displayed poorer mechanical properties. Sustained releasing blend electrospun scaffold could be a good potential candidate as an ASP-eluting scaffold for bone tissue engineering. View Full-Text
Keywords: electrospinning; ascorbate-2-phosphate; release electrospinning; ascorbate-2-phosphate; release

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zhao, X.; Lui, Y.S.; Toh, P.W.J.; Loo, S.C.J. Sustained Release of Hydrophilic l-ascorbic acid 2-phosphate Magnesium from Electrospun Polycaprolactone Scaffold—A Study across Blend, Coaxial, and Emulsion Electrospinning Techniques. Materials 2014, 7, 7398-7408.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top