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Characterization and Stability of Tanshinone IIA Solid Dispersions with Hydroxyapatite
State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 24 tongjiaxiang, Nanjing 210009, China
Department of Pharmacy, the Second Affiliated Hospital, Nanjing Medical University, No. 121 jiangjiayuan, Nanjing 210028, China
These authors contributed equally to this work.
* Authors to whom correspondence should be addressed.
Received: 28 December 2012; in revised form: 19 February 2013 / Accepted: 28 February 2013 / Published: 6 March 2013
Abstract: Solid dispersions of tanshinone IIA (TanIIA) using hydroxyapatite (HAp) as the dispersing carrier (TanIIA-HAp SDs) were prepared by the solvent evaporation method. The formed solid dispersions were characterized by scanning electron microscopy (SEM), differential scanning calorimetry analysis (DSC), X-ray powder diffraction (XRPD) and Fourier transforms infrared (FTIR) spectroscopy. The in vitro dissolution rate and the stability of TanIIA-HAp SDs were also evaluated. DSC and XRPD showed that TanIIA was changed from a crystalline to an amorphous form. FTIR suggested the presence of interactions between TanIIA and HAp in solid dispersions. The result of an in vitro dissolution study showed that the dissolution rate of TanIIA-HAp SDs was nearly 7.11-folds faster than free TanIIA. Data from stability studies for over one year of TanIIA-HAp SDs performed under room temperature revealed no significant differences in drug content and dissolution behavior. All these results indicated that HAp may be a promising carrier for improving the oral absorption of TanIIA.
Keywords: TanIIA; hydroxyapatite; solid dispersions
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MDPI and ACS Style
Wang, X.; Li, L.; Huo, W.; Hou, L.; Zhao, Z.; Li, W. Characterization and Stability of Tanshinone IIA Solid Dispersions with Hydroxyapatite. Materials 2013, 6, 805-816.
Wang X, Li L, Huo W, Hou L, Zhao Z, Li W. Characterization and Stability of Tanshinone IIA Solid Dispersions with Hydroxyapatite. Materials. 2013; 6(3):805-816.
Wang, Xiaopan; Li, Li; Huo, Wei; Hou, Lulu; Zhao, Zhiying; Li, Weiguang. 2013. "Characterization and Stability of Tanshinone IIA Solid Dispersions with Hydroxyapatite." Materials 6, no. 3: 805-816.