Materials 2013, 6(3), 1011-1027; doi:10.3390/ma6031011

Graphene versus Multi-Walled Carbon Nanotubes for Electrochemical Glucose Biosensing

Received: 16 February 2013; in revised form: 7 March 2013 / Accepted: 8 March 2013 / Published: 14 March 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: : A simple procedure was developed for the fabrication of electrochemical glucose biosensors using glucose oxidase (GOx), with graphene or multi-walled carbon nanotubes (MWCNTs). Graphene and MWCNTs were dispersed in 0.25% 3-aminopropyltriethoxysilane (APTES) and drop cast on 1% KOH-pre-treated glassy carbon electrodes (GCEs). The EDC (1-ethyl-(3-dimethylaminopropyl) carbodiimide)-activated GOx was then bound covalently on the graphene- or MWCNT-modified GCE. Both the graphene- and MWCNT-based biosensors detected the entire pathophysiological range of blood glucose in humans, 1.4–27.9 mM. However, the direct electron transfer (DET) between GOx and the modified GCE’s surface was only observed for the MWCNT-based biosensor. The MWCNT-based glucose biosensor also provided over a four-fold higher current signal than its graphene counterpart. Several interfering substances, including drug metabolites, provoked negligible interference at pathological levels for both the MWCNT- and graphene-based biosensors. However, the former was more prone to interfering substances and drug metabolites at extremely pathological concentrations than its graphene counterpart.
Keywords: graphene; multi-walled carbon nanotubes; electrochemical glucose sensor; glucose oxidase
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MDPI and ACS Style

Zheng, D.; Vashist, S.K.; Dykas, M.M.; Saha, S.; Al-Rubeaan, K.; Lam, E.; Luong, J.H.; Sheu, F.-S. Graphene versus Multi-Walled Carbon Nanotubes for Electrochemical Glucose Biosensing. Materials 2013, 6, 1011-1027.

AMA Style

Zheng D, Vashist SK, Dykas MM, Saha S, Al-Rubeaan K, Lam E, Luong JH, Sheu F-S. Graphene versus Multi-Walled Carbon Nanotubes for Electrochemical Glucose Biosensing. Materials. 2013; 6(3):1011-1027.

Chicago/Turabian Style

Zheng, Dan; Vashist, Sandeep K.; Dykas, Michal M.; Saha, Surajit; Al-Rubeaan, Khalid; Lam, Edmond; Luong, John H.; Sheu, Fwu-Shan. 2013. "Graphene versus Multi-Walled Carbon Nanotubes for Electrochemical Glucose Biosensing." Materials 6, no. 3: 1011-1027.

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