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In Vivo Degradation Behavior of the Magnesium Alloy LANd442 in Rabbit Tibiae
Small Animal Clinic, University of Veterinary Medicine Hanover Foundation, Buenteweg 9, Hanover 30559, Germany
Hannover Centre for Production Technology, Institute of Materials Science, Leibniz University of Hanover, An der Universitaet 2, Garbsen 30823, Germany
Clinic for Small Animal Surgery and Reproduction, Centre of Clinical Veterinary Medicine, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universitaet Muenchen, Veterinaerstr. 13, Munich 80539, Germany
* Author to whom correspondence should be addressed.
Received: 21 November 2011; in revised form: 2 December 2011 / Accepted: 9 December 2011 / Published: 15 December 2011
Abstract: In former studies the magnesium alloy LAE442 showed promising in vivo degradation behavior and biocompatibility. However, reproducibility might be enhanced by replacement of the rare earth composition metal “E” by only a single rare earth element. Therefore, it was the aim of this study to examine whether the substitution of “E” by neodymium (“Nd”) had an influence on the in vivo degradation rate. LANd442 implants were inserted into rabbit tibiae and rabbits were euthanized after 4, 8, 13 and 26 weeks postoperatively. In vivo µCT was performed to evaluate the in vivo implant degradation behaviour by calculation of implant volume, density true 3-D thickness and corrosion rates. Additionally, weight loss, type of corrosion and mechanical stability were appraised by SEM/EDS-analysis and three-point bending tests. Implant volume, density and true 3-D thickness decreased over time, whereas the variance of the maximum diameters within an implant as well as the corrosion rate and weight loss increased. SEM examination revealed mainly pitting corrosion after 26 weeks. The maximum bending forces decreased over time. In comparison to LAE442, the new alloy showed a slower, but more uneven degradation behavior and less mechanical stability. To summarize, LANd442 appeared suitable for low weight bearing bones but is inferior to LAE442 regarding its degradation morphology and strength.
Keywords: biodegradation; magnesium alloy; mechanical stability; animal model; µ-computed tomography
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Ullmann, B.; Reifenrath, J.; Dziuba, D.; Seitz, J.-M.; Bormann, D.; Meyer-Lindenberg, A. In Vivo Degradation Behavior of the Magnesium Alloy LANd442 in Rabbit Tibiae. Materials 2011, 4, 2197-2218.
Ullmann B, Reifenrath J, Dziuba D, Seitz J-M, Bormann D, Meyer-Lindenberg A. In Vivo Degradation Behavior of the Magnesium Alloy LANd442 in Rabbit Tibiae. Materials. 2011; 4(12):2197-2218.
Ullmann, Berit; Reifenrath, Janin; Dziuba, Dina; Seitz, Jan-Marten; Bormann, Dirk; Meyer-Lindenberg, Andrea. 2011. "In Vivo Degradation Behavior of the Magnesium Alloy LANd442 in Rabbit Tibiae." Materials 4, no. 12: 2197-2218.