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Biphasic Calcium Phosphate Ceramics for Bone Regeneration and Tissue Engineering Applications
Department of Morphology, Federal University of São Paulo, Rua Botucatu, 740, CEP 04023-900, São Paulo, SP, Brazil
Department of Biomedical Engineering, New Jersey Institute of Technology, University Heights; 614 Fenster Hall, Newark, NJ 07102-1982, USA
* Author to whom correspondence should be addressed.
Received: 1 December 2009; in revised form: 17 January 2010 / Accepted: 27 January 2010 / Published: 29 January 2010
Abstract: Biphasic calcium phosphates (BCP) have been sought after as biomaterials for the reconstruction of bone defects in maxillofacial, dental and orthopaedic applications. They have demonstrated proven biocompatibility, osteoconductivity, safety and predictability in in vitro, in vivo and clinical models. More recently, in vitro and in vivo studies have shown that BCP can be osteoinductive. In the field of tissue engineering, they represent promising scaffolds capable of carrying and modulating the behavior of stem cells. This review article will highlight the latest advancements in the use of BCP and the characteristics that create a unique microenvironment that favors bone regeneration.
Keywords: calcium phosphate ceramics; bone reconstruction; tissue engineering; stem cell
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MDPI and ACS Style
Lobo, S.E.; Livingston Arinzeh, T. Biphasic Calcium Phosphate Ceramics for Bone Regeneration and Tissue Engineering Applications. Materials 2010, 3, 815-826.
Lobo SE, Livingston Arinzeh T. Biphasic Calcium Phosphate Ceramics for Bone Regeneration and Tissue Engineering Applications. Materials. 2010; 3(2):815-826.
Lobo, Sonja Ellen; Livingston Arinzeh, Treena. 2010. "Biphasic Calcium Phosphate Ceramics for Bone Regeneration and Tissue Engineering Applications." Materials 3, no. 2: 815-826.