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• Bercier, A
• Gonçalves, S
• Autefage, H
• Briand-Mesange, F
• Lignon, O
• Fitremann, J
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• Gonçalves, S
• Autefage, H
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• Gonçalves, S
• Autefage, H
• Briand-Mesange, F
• Lignon, O
• Fitremann, J

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Materials 2010, 3(12), 5111-5129; doi:10.3390/ma3125111

Article

Calcium Phosphate Bone Cements Including Sugar Surfactants: Part Two—Injectability, Adhesive Properties and Biocompatibility

Ariane Bercier ¹, Stéphane Gonçalves ², Helène Autefage ³, Fabienne Briand-Mesange ³, Olivier Lignon ² and Juliette Fitremann ^1,*

¹ Université de Toulouse, Laboratoire des IMRCP, CNRS-Université Paul Sabatier, Bâtiment 2R1, 118 Route de Narbonne, 31062 Toulouse Cedex 9, France ² Teknimed SA, 11 rue Apollo, ZI Montredon, 31240 L'UNION, France ³ Unité INSERM 563, CPTP, Dpt. LML, Bâtiment C, Hôpital de Purpan, BP3028, 31024 Toulouse cedex 3, France

* Author to whom correspondence should be addressed.

Received: 18 October 2010; Accepted: 30 November 2010 / Published: 2 December 2010

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Abstract: Addition of sugar surfactants, sucrose fatty acid esters and alkylpolyglucosides to a calcium phosphate cement, designed for bone reconstruction, is described. Thanks to their adsorption at the surface of the calcium phosphate particles, the sugar surfactants allowed a full injectability and brought a very good workability. Injectability was measured by monitoring force-distance curves. With some of the selected sugar surfactants adhesive properties of the cement pastes were also observed, which were measured by tack tests. Finally, some properties related to biological applications are described, including gentamicine release and osteoblast viability experiments. The whole study demonstrates that addition of these mild surfactants improved several properties of the calcium phosphate cement, without impairing function.

Keywords: calcium phosphate; surfactant; sugar; injectability; adhesiveness; sticky

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