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Article

Determination, Modeling and Evaluation of Kinetics of 223Ra Sorption on Hydroxyapatite and Titanium Dioxide Nanoparticles

Faculty of Nuclear Sciences and Physical Engineering, Department of Nuclear Chemistry, Czech Technical University in Prague, Břehová 7, 11519 Prague 1, Czech Republic
*
Author to whom correspondence should be addressed.
Materials 2020, 13(8), 1915; https://doi.org/10.3390/ma13081915
Submission received: 28 March 2020 / Revised: 14 April 2020 / Accepted: 15 April 2020 / Published: 19 April 2020
(This article belongs to the Special Issue Advanced Systems in Targeted Alpha Particle Therapy)

Abstract

:
Sorption kinetics of radium on hydroxyapatite and titanium dioxide nanomaterials were studied. The main aim of the current study was to determine the rate-controlling process and the corresponding kinetic model, due to the application of studied nanomaterials as α-emitters’ carriers, and to assess the sorption properties of both materials from the radiopharmaceutical point of view by time regulated sorption experiments on the nanoparticles. Radium-223 was investigated as radionuclide used in targeted alpha particle therapy as an in vivo generator. It was found that the controlling process of the 223Ra sorption kinetics was the diffusion in a reacted layer. Therefore, parameters like particle size, their specific surface area, contact time and temperature played important role. Moreover, the composition of liquid phase, such as pH, the concentration of 223Ra, ionic strength, the presence of complexation ligands, etc., had to be considered. Experiments were conducted under free air conditions and at pH 8 for hydroxyapatite and pH 6 for titanium dioxide in Britton–Robinson buffer. Initial 223Ra concentration was in the range from 10−11 to 10−12 mol/L. It was found that sorption kinetics was very fast (more than 90% in the first hour) in the case of both nanomaterials, so they can be directly used for efficient radium sorption.

Graphical Abstract

1. Introduction

Both studied materials, hydroxyapatite (Hap) and titanium dioxide are situated among natural sorbents. Their properties were studied in the case of inorganic and organic contaminants’ separation from different types of waters [1,2,3,4,5]. Recently, the attention was devoted to nanoparticles (NPs) because of their large specific surface area that leads to relatively fast either sorption or desorption kinetics and high sorption capacity. Especially, the pH dependent sorption properties, based on the protonation or deprotonation of surface sites [1,6,7,8,9], enable the sorption of cationic or anionic species on studied nanoparticles by ion exchange and surface-complexation mechanism simultaneously [6,8,9,10,11].
Another advantage of both materials is their biocompatibility. Hydroxyapatite—(Ca10(PO4)6(OH)2)—is the natural component of bones and its synthetic analogue is widely used as artificial bones, adsorbent for protein chromatography, additive in toothpastes, etc. [2]. Several studies focusing on adsorption of various substances onto hydroxyapatite, such as icariin [12], organic dyes [13], Pb2+ [2,3,14], Cd2+ [2,15], etc., were already published. They were dealing with contaminant retention and purification. It was found that the retention kinetics of the Hap could be quite fast and strongly depending on the substance. For substances, which do not react with Hap—i.e., their retention mechanism has physical character—it took approximately 15 min [12,13]. In the case of cations, which could interact with the Hap structure, required time for the reaction was in the range from 15 min to 1.5 h for different ions. Sorption capacity also belongs to important parameters. It was found that sorption capacity of Hap was up to 500 mg/g for Pb [3,14]. Due to those facts, Hap can be used not only as a sorbent for contamination removal, but also as a carrier for different radionuclides [2,3,14,15].
Titanium dioxide is widely used in food technology as a pigment known as E171, moreover, TiO2 is used as a filling material in drugs or cosmetics. However, sorption properties of TiO2, which were studied in this paper, were being investigated for a very long time. For example, 68Ge/68Ga generators used in nuclear medicine are packed with titania [16]. Another way to use TiO2 as a sorbent was the treatment technique for pollutant removing from the environment. Several studies were involved in the research of suitable conditions for removing organic contaminants, such as dyes [4], dioxane, N-nitrosodimethylamine (NDMA), tris-2-chloroethyl phosphate (TCEP) and estradiol [17], oxalic acid [18], and inorganic ions, such as Zn2+ [5], As3+ and As5+ [19,20], Fe2+ [21], etc. mainly from water. According to the above-mentioned studies, sorption kinetics of TiO2 were rather fast, lasted from several minutes to few hours, and was depended on the type of contaminant. Sorption capacity of TiO2 was reported to be about 5 mg/g for the most ions [22].
The radioisotope 223Ra (T1/2 = 11.4 d) was chosen for the study due to its beneficial properties as an in vivo generator for targeted alpha therapy. Alpha emitting radionuclides are able to damage cells including DNA strand, and in the case of correct radionuclide-carrier combination could be very powerful in cancer treatment [23]. Radium-223 chloride (Xofigo®) is already used for palliative treatment of bone metastases of prostate cancer [24,25] due to its chemical behavior similar to calcium. Unfortunately, the application of Xofigo® had to be restricted due to found side effects during ongoing clinical studies. Nowadays, Xofigo® can be used only in several specific indications. This recommendation went from Pharmacovigilance Risk Assessment Committee (European Medicines Agency) [26]. Due to these recommendations and for the possibility of other organs treatment, it is necessary to create an appropriate carrier, which will immobilize the radionuclide and its decay products and drive into the tissue of interest. During the alpha decay a lot of energy is released and about 95% is carried by alpha particle (in the case of 223Ra it is approximately 5 MeV), and the rest, 5%, is carried by the new nucleus. Therefore, the bond between radionuclide and organic molecule is destroyed, because the nucleus energy is much higher than the energy of chemical bond [23]. For this and other reasons, e.g., the radiation stability, it is better to choose inorganic materials as carriers. So, in order to immobilize 223Ra and its daughter radionuclides, hydroxyapatite (nHAp) and titanium dioxide nanoparticles (nTiO2) were chosen.
The subject and goal of this study can be conceived as follows: (a) to summarize sorption kinetic models derived for two phase systems, (b) to evaluate the time dependent concentrations of 223Ra(II) with the aim of identifying the rate-controlling sorption process and to find the corresponding kinetic model, and (c) to assess the influence of the basic reaction parameters. Surface protolytic properties [6], dependence of sorption on pH [10], and sorbed species of 223Ra [10] were already studied and described in detail. Current paper continues the study on nHAp and nTiO2 as perspective materials for nuclear medicine as a radionuclide vehicle.

2. Materials and Methods

All chemicals were of analytical grade purchased from Merck (Darmstadt, Germany) and were used without further purification: tetrabutyl ortho-titanate (TBOT), prop an-2-ol (IPA), sodium hydroxide, phosphoric acid, boric acid, acetic acid, sodium nitrate, ammonium hydroxide solution (28%), calcium nitrate tetrahydrate, and ammonium hydrogen phosphate. Demineralized water of 18 MΩ/cm was obtained from Millipore, (Burlington, MA, USA) water purification system.
Radioactivity measurement was performed on CRC-55tW (CAPINTEC, Ramsey, NJ, USA) calibrated detector. During the experiments, all samples were mixed with curved glass stick fixed in IKA RW 11 stirrer (Staufen, Germany), centrifugation was performed on Centrifuge MPW-360 (MPW, Warsaw, Poland).

2.1. Preparation of 223Ra Stock Solution

Radium-223 generator (227Ac/227Th/223Ra) was prepared in our laboratory according to Guseva et al. [27]. The elution was performed by 0.7 M nitric acid in 80% methanol solution from column (0.5 g of Dowex-1 × 8 and 227Ac in equilibrium with its decay products) for the separation of 223Ra stock solution from 227Ac and 227Th. The gained 223Ra in the form of 223Ra(NO3)2 was dried and reconstituted with saline. No breakthrough of parent radionuclides was observed in γ-spectrum of the eluate.

2.2. Britton–Robinson Buffer Solution

The necessary Britton–Robinson buffer (BRB) was prepared from two stock solutions, which were mixed in an appropriate ratio. The first one was 0.2 M sodium hydroxide and the second one was the mixture of 0.04 M phosphoric acid, 0.04 M boric acid, and 0.04 M acetic acids.

2.3. Sorbent Material Preparation

Hydroxyapatite nanoparticles were prepared by using equal volumes of 1.2 M Ca(NO3)2 and 0.7 M (NH4)2HPO4 in order to obtain the Ca:P = 1.67 ratio. At first, the calcium salt solution was added to 0.5 L of demineralized water. The pH of the mixture was set to 11 and maintained during the reaction. Then (NH4)2HPO4 was added dropwise during stirring. After overnight stirring, gained NPs were washed (demineralized water–three times) and dried under vacuum.
Mixture of TBOT and IPA (1:4) was used for titanium dioxide nanoparticles preparation. The mixture was added dropwise into excess of demineralized water under ultrasonication. The whole mixture was in ultrasonic generator for 30 min. Gained NPs were washed (demineralized water–three times, IPA–once) and then dried under vacuum. Detailed description of the materials preparation and characterization was published by Kukleva et al. [6] earlier.

2.4. Determination of Kinetic Dependences

The pH of following kinetic experiments was set to eight for nHAp and to six for nTiO2 according to the study of 223Ra uptake mechanism by NPs as a function of pH described by Suchánková et al. [10] and future planned use of these materials in medicine in vivo. Prepared sorbents were dispersed in 25 mL of BRB, so the concentration of NPs was 1 g/L. Then 223Ra(NO3)2 solution of similar pH was added, so average activity per sample was 200 kBq. The suspension was continuously stirred during the whole experiment (24 h). Small aliquots of suspension (0.5 mL) were taken from the sample in 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 40, 50, and 60 min and then after 2, 3, 4, 5, 7, 10, and 24 h, so the solid to liquid phase ratio remained constant. The zero aliquot was taken immediately after 223Ra solution addition. The aliquots were centrifuged for 30 s at 3000 rpm in the case of nHAp and 40 s at 4000 rpm in the case of nTiO2, due to different stability of nanomaterial dispersion. After separation, nanoparticles were redispersed in 0.5 mL of water to ensure uniform counting geometry. The radiochemical yield (Y %) of adsorbed 223Ra was calculated based on activity measurements of separated supernatant (As) and nanoparticles (Ap) according to Equation (1):
Y   ( % ) = A s A s + A p × 100 %
Based on 223Ra absolute activity the concentration in the solution was calculated using Equation (2):
c = A × T 1 / 2 ln 2 × V a q × N A   [ m o l · L 1 ]
where A (Bq) is the absolute activity of the radionuclide, T1/2 (s) is the radionuclide half-life, Vaq (L) is the volume of the solution, and NA is the Avogadro constant.
The experiments were repeated three times for each sorbent.

2.5. Kinetic Models for Two-Phase Systems

Kinetic models are summarized in Table 1 [28] and reflect the following different rate-controlling processes: mass transfer (DM), film diffusion (FD), diffusion in inert layer (ID), diffusion in reacted layer (RLD), chemical reaction (CR), and gel diffusion (GD). All of these models are given by first order differential equations.

2.6. Procedure of the Experimental Data Evaluation

The RLD-model was used to demonstrate calculations of the liquid–solid sorption kinetics in detail (Equations (8) and (9)). The systems were following 223Ra(II)nHAp and 223Ra(II)nTiO2. Sorption from the aqueous phase into the solid sorbent is described by the Equation (8), which was modified with balance and equilibrium equations (Equations (15) and (18)). The obtained equation can be used for direct evaluation of the experimental data. The value of the over-all mass transfer coefficient, KRLD, was sought based on the Newton–Raphson multidimensional non-linear regression method combined with the solution of the differential equation under given boundary conditions (Runge–Kutha method). Calculations were performed on in-house made code P60.fm of software product FAMULUS (Famulus Etc., Prague, Czech Republic) [28].
If the value of WSOS/DF (weighted sum of squares divided by degrees of freedom) was in the range from 0.1 to 20 [29], the evaluated model was taken as suitable. The calculations were based on the χ2—test according to Equation (19). Based on Equation (20) the value of WSOS/DF was obtained.
Χ2 = ∑{(SSx)i/(sq)i2}}; i = 1, 2, 3, …, np,
WSOS/DF = (χ2/nd); nd = npn,
where (SSx)I is the i-th square of the deviation of i-the experimental value from the corresponding calculated one, (sq)I is the estimate of standard deviation (uncertainty) of the i-the experimental point, np is the number of experimental points, nd is the number of degrees of freedom, and n is the number of model parameters sought during the regression procedure.

3. Results and Discussion

3.1. Parameters of nHAp and nTiO2

As mentioned above, the preparation and characterization of the sorbents was published earlier by Kukleva et al. [6] and the pH values were chosen in terms of 223Ra sorption mechanism results published by Suchánková et al. [10]. Characterization parameters of the sorbents are summarized in Table 2. The significant differences can be seen in the values of specific surface area determined by the Brunauer–Emmett–Teller (B.E.T.) method, crystallite size and equivalent diameter of NPs. Based on this data, higher kinetic rate should be expected in the case of nTiO2 than of nHAp. However, nHAp has higher concentration of surface edge sites, which can be interpreted as its potential higher sorption capacity for species present under pH ≥ 8–9 [6], but the radionuclide concentration was very low (Table 3), so this advantage has probably not played an important role.

3.2. Evaluation of Kinetic Dependence

The parameters used as input data, in addition to experimental time dependent concentrations (Figure 1a,b), are summarized in Table 3. Values of Kd were obtained from equilibrium values of given kinetic experiments.
Primarily, each of the experimental kinetic dependence was fitted by all six models one by one (Table 1) and then evaluated based on the WSOS/DF value (Table 4). According to WSOS/DF values, only two models (ID and RLD) were found suitable for further modeling and description of the experimental results. However, RLD model better corresponds with the studied systems from the physical–chemical point of view, therefore it was chosen for further evaluation. Namely, the diffusion through reacted layer seems to be more realistic than through the inert one.
The experimental and calculated data are illustrated as time dependent percentage fraction of 223Ra sorbed on nHAp (Figure 1a) and on nTiO2 (Figure 1b) together with error bars. Due to the fast sorption kinetics, frequent sampling, very low radium concentration, and precautions applied for the work with radioactive materials, experimental errors, i.e., error bars, seem to be relatively high. However, all three repeated experiments for both materials were evaluated separately and the resulted mean values of: overall mass transfer coefficient, KRLD; diffusion coefficient, D, and sorption half-life, t1/2, are summarized with their correspond values of standard uncertainties, σes, in Table 5 (the results also include the mean Kd values). As for the sorption half-life, t1/2, it represents the time needed for a sorption to increase by half compared to its maximal (equilibrium) level in the given kinetic experiment. The diffusion coefficient in the solid phase, D, is determined using Equation (9) (mean radius of the solid phase particle, R, and its specific mass density, hs, can be found in Table 2). It is obvious that among the parameters mentioned above the most important, from the kinetic point of view, especially for NPs is mean radius, R, in addition to specific surface area (Table 2). Diffusion coefficient, D, depends on the temperature, type, and speciation of given component (in this case of 223Ra as RaHPO4, RaH2PO4+, and Ra2+) [10,30]. Distribution coefficient, Kd, is responsible for the value of driving force of the given transport process ((q* − q) or (cc*) in Table 1). The larger Kd, the larger driving force especially during first seconds or minutes and the larger positive contribution to the rate of kinetic process. This contribution to the increase in sorption rate is, as we believe, characterized by the half-life t1/2. If we compare the mean values of t1/2 ± σ (Table 5) with the mean values of Kd ± σ (Table 3) then we can conclude that the mean values have approximately comparable statistical significance and that their values correlate with each other. In our opinion, this indicates the positive impact of Kd on the rate of the sorption process.
Comparing the mean values of KRLD (Table 5), at first glance it seems that the sorption on nHAp ought to be faster than on nTiO2. Of course, it does not hold true because the difference in KRLD values is in consequence of the reversible character of the sorption process studied. Especially in this case, it is the dependence of the sorption rate on the driving force given by the value Kd, as mentioned above. The half-lives of the sorption reaction, t1/2 (Table 5), were considered as the quantification of this effect, the mean values of which were 0.75 ± 0.18 min and 0.51 ± 0.32 min for nHAp and nTiO2 respectively. Based not only on these values, but also on the values of R, Kd, and specific surface area, the sorption kinetics on nTiO2 can be validated as faster than on nHAp.

4. Conclusions

The sorption kinetics of 223Ra to nHAp and nTiO2 were experimentally studied under free air conditions at 22 ± 1 °C. (a) There were summarized sorption kinetic models for the two phase system. The results were evaluated using six different kinetic models of a two-phase system, derived for six different rate control processes, based on first-order differential equations. (b) According to goodness-of-fit values, WSOS/DF, the model based on diffusion in the reacted layer (RLD) of the solid phase was chosen as the best for both types of sorbents studied. (c) Further, the influence of the basic reaction parameters was assessed. It was found that nTiO2 had higher value of Kd compared to nHAp, which could be understood not only as higher sorption capacity for 223Ra under given reaction conditions, but also as higher time dependent driving force in the course of given kinetics, which contributes to a higher sorption rate on nTiO2. This was confirmed by the values of half-life reaction quantity, t1/2, nTiO2. This corresponded with the larger specific surface area of nTiO2 and its smaller particle diameter. Unfortunately, the values of overall kinetic coefficients, KRLD, on the basis of the first quick look, pointed to the opposite result. However, it is necessary to take into account the reversible nature of the sorption reaction, which implies that the parameter of the sorption kinetics is not only KLRD, but also Kd, i.e., the driving force of the given reaction. In any case, the 223Ra sorption rate is sufficient and serves the purpose of nHAp and nTiO2 for medicinal and industrial applications.

Author Contributions

Conceptualization, P.S. and J.K.; methodology, P.S., E.K. and K.Š.; software, K.Š.; validation, P.S., P.N. and M.S.; formal analysis, E.K. and K.Š.; investigation, P.S., P.N., M.S. and E.K.; resources, M.V.; data curation, P.S., M.S., E.K. and M.V.; writing—original draft preparation, P.S.; writing—review and editing, E.K.; visualization, E.K. and J.K.; supervision, J.K.; project administration, J.K. and M.V.; funding acquisition, P.S., J.K. and M.V. All authors have read and agreed to the published version of the manuscript.

Funding

This research was funded by CZECH TECHNICAL UNIVERSITY IN PRAGUE, grant number SGS19/194/OHK4/3T/14, TECHNOLOGY AGENCY OF THE CZECH REPUBLIC, grant number TA03010027, HEALTH RESEARCH AGENCY OF THE CZECH REPUBLIC, grant number NV16-30544A and the EU and the Ministry of Education, Youth and Sports of the Czech Republic, grant number CZ.02.1.01/0.0/0.0/15_003/0000464.

Conflicts of Interest

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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Figure 1. The kinetic of 223Ra sorption on nanoparticles (NPs) during the first hour: (a) nHAp (mean initial concentration c0 = 1.02 × 10−11 mol/L) and (b) nTiO2 (mean initial concentration c0 = 1.01 × 10−11 mol/L).
Figure 1. The kinetic of 223Ra sorption on nanoparticles (NPs) during the first hour: (a) nHAp (mean initial concentration c0 = 1.02 × 10−11 mol/L) and (b) nTiO2 (mean initial concentration c0 = 1.01 × 10−11 mol/L).
Materials 13 01915 g001
Table 1. Kinetic models of sorption/extraction taking place in two-phase systems [28].
Table 1. Kinetic models of sorption/extraction taking place in two-phase systems [28].
Control ProcessModel AbbreviationDifferential EquationEquation #
Mass transferDMdq/dt = KDM × (q* − q)(3)
Film diffusionFDdq/dt = KFD × (cc*)(4)
KFD = 3 × D/(δ × R × hs)(5)
DiffusionIDdq/dt = KID × (cc*)/{[1 − (q/q*)]−1/3 − 1}(6)
in an inert layerKID = 3 × D/(R2 × hs)(7)
DiffusionRLDdq/dt = KRLD × (q* − q)/{[1 − (q/q*)]−1/3 − 1}(8)
in a reacted layerKRLD = 3 × D/(R2 × hs)(9)
Chemical reactionCRdq/dt = KCR × rCR × [1 − (q/q*)]2/3(10)
in the reaction zone,KCR = 3/(R × hs)(11)
e.g., 1st order reversible reactionRCR = KCR × (cc*)(12)
Gel diffusionGDdq/dt = KGD × [(q* − q0)2 − (qq0)2]/(qq0)(13)
KGD = D × π2/(2 × R2)(14)
Following balance equations hold:
dq/dt = −r × dc/dt(15)
if c is the integration variable: q = r × (c0c) + q0(16)
if q is the integration variable: c = c0 − (qq0)/r(17)
Equilibrium equations used: q* = Kd × c, and c* = q/Kd(18)
c is a concentration of the component in the aqueous phase at time t; c*—equilibrium concentration of the component in the aqueous phase corresponding to the concentration of the component in the sorbent at time t; q—concentration of the component in the sorbent at time t; q*—equilibrium concentration of the component in the sorbent corresponding to the concentration of the component in the aqueous phase at time t; q0—starting concentration of the component in the sorbent; t—time; r—volume ratio of aqueous to solid phase; D—diffusion coefficient of the component, KDM; KFD, KID, KRLD, KCR, and KGD—over-all kinetic coefficients; kCR—kinetic coefficient of the chemical reaction; rCR—rate of the chemical reaction; R—mean radius of the solid phase particle; hs—specific mass of the solid sorbent; and δ—thickness of the “liquid film” on the surface of the solid particle.
Table 2. The basic properties of nHAp and nTiO2 [6,10].
Table 2. The basic properties of nHAp and nTiO2 [6,10].
ParameterUnitnHApnTiO2
Specific surface area(m2·kg−1)117 ± 8330 ± 10
Crystallite size(nm)5.182.64
Equivalent diameter(nm)21.7 ± 6.95.3 ± 1.7
Surface edge sites(mol·kg−1)5.10 ± 1.200.20 ± 0.01
Surface layer sites(mol·kg−1)0.15 ± 0.010.67 ± 0.01
pH applicabilitypH5–102–10
Specific mass(g·cm−3)3.14–3.213.90–4.30
Table 3. Starting aqueous phase concentrations of 223Ra, c0, and the values of parameters Kd and r in kinetic experiments of sorption on nHAp and nTiO2 (at t = 0).
Table 3. Starting aqueous phase concentrations of 223Ra, c0, and the values of parameters Kd and r in kinetic experiments of sorption on nHAp and nTiO2 (at t = 0).
Experiment
No.
nHApnTiO2
c0Kdrc0Kdr
(mol·Laq−1)(Laq∙kg−1)(Laq∙kg−1)(mol·Laq−1)(Laq∙kg−1)(Laq∙kg−1)
19.92 × 10−123.03 × 10410001.01 × 10−115.90 × 1041000
29.46 × 10−121.55 × 10410001.05 × 10−111.25 × 1051000
31.12 × 10−111.54 × 10410009.86 × 10−121.52 × 1051000
Mean value ± σes *1.02 × 10−11 ± 0.07 × 10−112.04 × 104 ± 0.70 × 10410001.01 × 10−11 ± 0.03 × 10−111.12 × 105 ± 0.39 × 1051000
(q0 = 0, in all cases); * σes: standard deviation based on the entire population given as arguments (MC Office Excel function STDEV.P).
Table 4. The evaluation of kinetic dependences by six different models (Table 1) based on the values of WSOS/DF (weighted sum of squares divided by degrees of freedom) characterizing the agreement between the experimental (22 ± 1 °C) and calculated data.
Table 4. The evaluation of kinetic dependences by six different models (Table 1) based on the values of WSOS/DF (weighted sum of squares divided by degrees of freedom) characterizing the agreement between the experimental (22 ± 1 °C) and calculated data.
SorbentExperiment No.WSOS/DF
DMFDIDRLDCRGD
nHAp159.7018605.355.47132040.30
28.281867.457.2592.6010.10
38.064612.602.7125027.60
Mean value ± σes *25.34 ± 24.29835.67 ± 732.965.13 ± 1.995.14 ± 1.87554.20 ± 545.3026.00 ± 12.38
nTiO2148.7054.706.727.6352.809.99
25.767571.233.1836.309.42
333.402588.0916.102395.43
Mean value ± σes *29.29 ± 17.77356.57 ± 295.065.35 ± 2.978.96 ± 5.36109.37 ± 91.918.27 ± 2.04
* σes: standard deviation based on the entire population given as arguments (MC Office Excel function STDEV.P).
Table 5. The values of over-all kinetic, KRLD, and diffusion, D, coefficients, and half-life of sorption, t1/2, for the diffusion in reacted layer (RLD) model.
Table 5. The values of over-all kinetic, KRLD, and diffusion, D, coefficients, and half-life of sorption, t1/2, for the diffusion in reacted layer (RLD) model.
SorbentExperiment
No.:
KRLD ± σ
(cm3·g−1·min−1)
Mean *
KRLD ± σes
(cm3·g−1·min−1)
Mean *
D ± σes
(cm2·min−1)
Mean *
t1/2 ± σes
(min)
nHAp11.24 × 10−15.03 × 10−1 ± 2.72 × 10−12.50 × 10−12 ± 1.80 × 10−120.75 ± 0.18
27.53 × 10−1
36.31 × 10−1
nTiO212.82 × 10−24.01 × 10−2 ± 2.44 × 10−21.60 × 10−14 ± 0.96 × 10−140.51 ± 0.32
21.80 × 10−2
30.74 × 10−2
* σes: standard deviation based on the entire population given as arguments (MC Office Excel function STDEV.P).

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Suchánková, P.; Kukleva, E.; Štamberg, K.; Nykl, P.; Sakmár, M.; Vlk, M.; Kozempel, J. Determination, Modeling and Evaluation of Kinetics of 223Ra Sorption on Hydroxyapatite and Titanium Dioxide Nanoparticles. Materials 2020, 13, 1915. https://doi.org/10.3390/ma13081915

AMA Style

Suchánková P, Kukleva E, Štamberg K, Nykl P, Sakmár M, Vlk M, Kozempel J. Determination, Modeling and Evaluation of Kinetics of 223Ra Sorption on Hydroxyapatite and Titanium Dioxide Nanoparticles. Materials. 2020; 13(8):1915. https://doi.org/10.3390/ma13081915

Chicago/Turabian Style

Suchánková, Petra, Ekaterina Kukleva, Karel Štamberg, Pavel Nykl, Michal Sakmár, Martin Vlk, and Ján Kozempel. 2020. "Determination, Modeling and Evaluation of Kinetics of 223Ra Sorption on Hydroxyapatite and Titanium Dioxide Nanoparticles" Materials 13, no. 8: 1915. https://doi.org/10.3390/ma13081915

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