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Materials 2018, 11(2), 258; https://doi.org/10.3390/ma11020258

Hydroxyapatite Microspheres as an Additive to Enhance Radiopacity, Biocompatibility, and Osteoconductivity of Poly(methyl methacrylate) Bone Cement

1
Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Korea
2
Biomedical Implant Convergence Research Center, Advanced Institutes of Convergence Technology, Suwon-si 16229, Korea
*
Author to whom correspondence should be addressed.
Received: 5 January 2018 / Revised: 2 February 2018 / Accepted: 5 February 2018 / Published: 7 February 2018
(This article belongs to the Section Biomaterials)
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Abstract

This study demonstrates the utility of hydroxyapatite (HA) microspheres as an additive to enhance the radiopaque properties, biocompatibility, and osteoconductivity of poly(methyl methacrylate) (PMMA)-based bone cements. HA microspheres were synthesized using spray drying. They had well-defined spherical shapes, thus allowing for the production of PMMA/HA composites with a very high HA content (20 vol % and 40 vol %). The uniform distribution of these HA microspheres in the PMMA matrix resulted in a remarkable increase in compressive modulus (p < 0.05), while preserving a reasonably high compressive strength. The PMMA/HA bone cements showed much higher radiopacity than PMMA containing BaSO4 as the additive. This was attributed to the high HA content up to 40 vol %. In addition, the biocompatibility and osteoconductivity of PMMA/HA bone cements were significantly enhanced compared to those of PMMA bone cements containing BaSO4, which were assessed using in vitro tests and in vivo animal experiments. View Full-Text
Keywords: bone cements; poly(methyl methacrylate); hydroxyapatite; radiopaque properties; osteoconductivity bone cements; poly(methyl methacrylate); hydroxyapatite; radiopaque properties; osteoconductivity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kang, I.-G.; Park, C.-I.; Lee, H.; Kim, H.-E.; Lee, S.-M. Hydroxyapatite Microspheres as an Additive to Enhance Radiopacity, Biocompatibility, and Osteoconductivity of Poly(methyl methacrylate) Bone Cement. Materials 2018, 11, 258.

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