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Materials 2017, 10(9), 1086; doi:10.3390/ma10091086

Impact of Source and Manufacturing of Collagen Matrices on Fibroblast Cell Growth and Platelet Aggregation

1
Technical Chemistry, Leibniz University Hannover, 30167 Hannover, Germany
2
Department of Biotechnology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria
*
Author to whom correspondence should be addressed.
Received: 10 July 2017 / Revised: 1 September 2017 / Accepted: 5 September 2017 / Published: 15 September 2017
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Abstract

Collagen is a main component of the extracellular matrix. It is often used in medical applications to support tissue regeneration, hemostasis, or wound healing. Due to different sources of collagen, the properties and performance of available products can vary significantly. In this in vitro study, a comparison of seven different collagen matrices derived from bovine, equine, and porcine sources was performed. As performance indicators, the scaffold function for fibroblasts and platelet aggregation were used. We found strong variation in platelet aggregation and fibroblast growth on the different collagen materials. The observed variations could not be attributed to species differences alone, but were highly dependent on differences in the manufacturing process. View Full-Text
Keywords: collagen scaffolds; fibroblasts; platelet aggregation; 3D cell culture collagen scaffolds; fibroblasts; platelet aggregation; 3D cell culture
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Böhm, S.; Strauß, C.; Stoiber, S.; Kasper, C.; Charwat, V. Impact of Source and Manufacturing of Collagen Matrices on Fibroblast Cell Growth and Platelet Aggregation. Materials 2017, 10, 1086.

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