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Materials 2017, 10(4), 411; doi:10.3390/ma10040411

Preparation and Characterization of Thermoresponsive Poly(N-isopropylacrylamide-co-acrylic acid)-Grafted Hollow Fe3O4/SiO2 Microspheres with Surface Holes for BSA Release

1
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
2
Department of Otorhinolaryngology Head & Neck Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou 510282, China
*
Author to whom correspondence should be addressed.
Academic Editor: Jordi Sort
Received: 6 March 2017 / Revised: 8 April 2017 / Accepted: 12 April 2017 / Published: 14 April 2017
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Abstract

Thermoresponsive P(NIPAM-AA)/Fe3O4/SiO2 microspheres with surface holes serving as carriers were prepared using p-Fe3O4/SiO2 microspheres with a thermoresponsive copolymer. The p-Fe3O4/SiO2 microspheres was obtained using a modified Pickering method and chemical etching. The surface pore size of p-Fe3O4/SiO2 microspheres was in the range of 18.3 nm~37.2 nm and the cavity size was approximately 60 nm, which are suitable for loading and transporting biological macromolecules. P(NIPAM-AA) was synthesized inside and outside of the p-Fe3O4/SiO2 microspheres via atom transfer radical polymerization of NIPAM, MBA and AA. The volume phase transition temperature (VPTT) of the specifically designed P(NIPAM-AA)/Fe3O4/SiO2 microspheres was 42.5 °C. The saturation magnetization of P(NIPAM-AA)/Fe3O4/SiO2 microspheres was 72.7 emu/g. The P(NIPAM-AA)/Fe3O4/SiO2 microspheres were used as carriers to study the loading and release behavior of BSA. This microsphere system shows potential for the loading of proteins as a drug delivery platform. View Full-Text
Keywords: P(NIPAM-AA); Fe3O4/SiO2 hollow microspheres; holes; drug release P(NIPAM-AA); Fe3O4/SiO2 hollow microspheres; holes; drug release
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Zhao, J.; Zeng, M.; Zheng, K.; He, X.; Xie, M.; Fu, X. Preparation and Characterization of Thermoresponsive Poly(N-isopropylacrylamide-co-acrylic acid)-Grafted Hollow Fe3O4/SiO2 Microspheres with Surface Holes for BSA Release. Materials 2017, 10, 411.

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