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Materials 2017, 10(2), 150; doi:10.3390/ma10020150

Investigating the Effects of Loading Factors on the In Vitro Pharmaceutical Performance of Mesoporous Materials as Drug Carriers for Ibuprofen

1
School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK
2
Quotient Clinical, Mere Way, Ruddington, Nottingham NG11 6JS, UK
*
Author to whom correspondence should be addressed.
Academic Editors: James Z. Tang and Charley Chuan-yu Wu
Received: 5 December 2016 / Revised: 31 January 2017 / Accepted: 2 February 2017 / Published: 9 February 2017
(This article belongs to the Special Issue Materials for Drug Delivery and Biomedical Consideration)
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Abstract

The aim of the study was to investigate the effects of the loading factors, i.e., the initial drug loading concentration and the ratio of the drug to carriers, on the in vitro pharmaceutical performance of drug-loaded mesoporous systems. Ibuprofen (IBU) was used as a model drug, and two non-ordered mesoporous materials of commercial silica Syloid® 244FP (S244FP) and Neusilin® US2 (NS2) were selected in the study. The IBU-loaded mesoporous samples were prepared by a solvent immersion method with a rotary evaporation drying technique and characterized by polarized light microscopy (PLM), Fourier transform infrared (FTIR) spectroscopy, X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC). Dissolution experiments were performed in simulated gastric media at 37 °C under non-sink conditions. The concentration of IBU in solution was determined by HPLC. The study showed that the dissolution rate of IBU can be improved significantly using the mesoporous S224FP carriers due to the conversion of crystalline IBU into the amorphous form. Both of the loading factors affected the IBU dissolution kinetics. Due to the molecular interaction between the IBU and NS2 carriers, the loading factors had little effects on the drug release kinetics with incomplete drug desorption recovery and insignificant dissolution enhancement. Care and extensive evaluation must therefore be taken when mesoporous materials are chosen as carrier delivery systems. View Full-Text
Keywords: mesoporous carriers; Syloid® 244FP; Neusilin® US2; poorly water-soluble drugs mesoporous carriers; Syloid® 244FP; Neusilin® US2; poorly water-soluble drugs
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MDPI and ACS Style

Lai, J.; Lin, W.; Scholes, P.; Li, M. Investigating the Effects of Loading Factors on the In Vitro Pharmaceutical Performance of Mesoporous Materials as Drug Carriers for Ibuprofen. Materials 2017, 10, 150.

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