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Materials 2017, 10(1), 74; doi:10.3390/ma10010074

Supercritical CO2-Assisted Spray Drying of Strawberry-Like Gold-Coated Magnetite Nanocomposites in Chitosan Powders for Inhalation

1
LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus de Caparica, Caparica 2829-516, Portugal
2
BIOSCOPE Research Group, UCIBIO@REQUIMTE, Chemistry Department, Faculty of Science and Technology, University NOVA of Lisbon, Caparica Campus, Caparica 2829-516, Portugal
3
CICS-UBI, Health Sciences Research Center, Faculdade de Ciências da Saúde, Universidade da Beira Interior, Av. Infante D. Henrique, Covilhã 6200-506, Portugal
4
PROTEOMASS Scientific Society, Rua dos Inventores, Madam Parque, Caparica Campus, Caparica 2829-516, Portugal
*
Authors to whom correspondence should be addressed.
Academic Editor: Maryam Tabrizian
Received: 29 July 2016 / Revised: 21 November 2016 / Accepted: 11 January 2017 / Published: 18 January 2017
(This article belongs to the Special Issue Selected papers from ISN2A2016)
View Full-Text   |   Download PDF [9852 KB, uploaded 18 January 2017]   |  

Abstract

Lung cancer is one of the leading causes of death worldwide. Therefore, it is of extreme importance to develop new systems that can deliver anticancer drugs into the site of action when initiating a treatment. Recently, the use of nanotechnology and particle engineering has enabled the development of new drug delivery platforms for pulmonary delivery. In this work, POXylated strawberry-like gold-coated magnetite nanocomposites and ibuprofen (IBP) were encapsulated into a chitosan matrix using Supercritical Assisted Spray Drying (SASD). The dry powder formulations showed adequate morphology and aerodynamic performances (fine particle fraction 48%–55% and aerodynamic diameter of 2.6–2.8 µm) for deep lung deposition through the pulmonary route. Moreover, the release kinetics of IBP was also investigated showing a faster release of the drug at pH 6.8, the pH of lung cancer. POXylated strawberry-like gold-coated magnetite nanocomposites proved to have suitable sizes for cellular internalization and their fluorescent capabilities enable their future use in in vitro cell based assays. As a proof-of-concept, the reported results show that these nano-in-micro formulations could be potential drug vehicles for pulmonary administration. View Full-Text
Keywords: lung diseases; dry powders; magnetic nanoparticles; nanocomposites; SASD; pulmonary delivery lung diseases; dry powders; magnetic nanoparticles; nanocomposites; SASD; pulmonary delivery
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MDPI and ACS Style

Silva, M.C.; Silva, A.S.; Fernandez-Lodeiro, J.; Casimiro, T.; Lodeiro, C.; Aguiar-Ricardo, A. Supercritical CO2-Assisted Spray Drying of Strawberry-Like Gold-Coated Magnetite Nanocomposites in Chitosan Powders for Inhalation. Materials 2017, 10, 74.

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