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Materials 2017, 10(1), 17; doi:10.3390/ma10010017

The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration

1
Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, Yangsan 50612, Korea
2
Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Korea
3
Department of Prosthodontics, Pusan National University Hospital, Pusan 49241, Korea
4
Tissue Biotech Institute, Cowellmedi Co., Ltd., Busan 46986, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Enrico Bernardo and Arne Berner
Received: 29 September 2016 / Revised: 1 December 2016 / Accepted: 6 December 2016 / Published: 1 January 2017
(This article belongs to the Section Biomaterials)
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Abstract

In this study, bisphasic calcium phosphate (BCP) and two types of polysaccharide, carboxymethyl cellulose (CMC) and hyaluronic acid (HyA), were used to fabricate composite block bone grafts, and their physical and biological features and performances were compared and evaluated in vitro and in vivo. Specimens of the following were prepared as 6 mm diameter, 2 mm thick discs; BPC mixed with CMC (the BCP/CMC group), BCP mixed with crosslinked CMC (the BCP/c-CMC group) and BCP mixed with HyA (the BCP/HyA group) and a control group (specimens were prepared using particle type BCP). A scanning electron microscope study, a compressive strength analysis, and a cytotoxicity assessment were conducted. Graft materials were implanted in each of four circular defects of 6 mm diameter in calvarial bone in seven rabbits. Animals were sacrificed after four weeks for micro-CT and histomorphometric analyses, and the findings obtained were used to calculate new bone volumes (mm3) and area percentages (%). It was found that these two values were significantly higher in the BCP/c-CMC group than in the other three groups (p < 0.05). Within the limitations of this study, BCP composite block bone graft material incorporating crosslinked CMC has potential utility when bone augmentation is needed. View Full-Text
Keywords: bone regeneration; bone substitutes; composite; biphasic calcium phosphate; carboxymethyl cellulose; crosslinking; hyaluronic acid bone regeneration; bone substitutes; composite; biphasic calcium phosphate; carboxymethyl cellulose; crosslinking; hyaluronic acid
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yoo, H.-S.; Bae, J.-H.; Kim, S.-E.; Bae, E.-B.; Kim, S.-Y.; Choi, K.-H.; Moon, K.-O.; Jeong, C.-M.; Huh, J.-B. The Effect of Bisphasic Calcium Phosphate Block Bone Graft Materials with Polysaccharides on Bone Regeneration. Materials 2017, 10, 17.

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