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First International Symposium on Recent Advances in Environmental Health Research
Int. J. Environ. Res. Public Health 2005, 2(1), 4-9; doi:10.3390/ijerph2005010004

Systems Biology: New Approaches to Old Environmental Health Problems

1,*  and 2
1 Div. of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, MN 55455, USA 2 Minnesota Department of Health, Minneapolis MN 55440-9441, USA
* Author to whom correspondence should be addressed.
Received: 15 November 2004 / Accepted: 6 February 2005 / Published: 30 April 2005
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The environment plays a pivotal role as a human health determinant and presence of hazardous pollutants in the environment is often implicated in human disease. That pollutants cause human diseases however is often controversial because data connecting exposure to environmental hazards and human diseases are not well defined, except for some cancers and syndromes such as asthma. Understanding the complex nature of human-environment interactions and the role they play in determining the state of human health is one of the more compelling problems in public health. We are becoming more aware that the reductionist approach promulgated by current methods has not, and will not yield answers to the broad questions of population health risk analysis. If substantive applications of environment-gene interactions are to be made, it is important to move to a systems level approach, to take advantage of epidemiology and molecular genomic advances. Systems biology is the integration of genomics, transcriptomics, proteomics, and metabolomics together with computer technology approaches to elucidate environmentally caused disease in humans. We discuss the applications of environmental systems biology as a route to solution of environmental health problems.
Keywords: genomics; envirome; exposure; systems analysis; toxicology; environmental health genomics; envirome; exposure; systems analysis; toxicology; environmental health
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Toscano, W.A.; Oehlke, K.P. Systems Biology: New Approaches to Old Environmental Health Problems. Int. J. Environ. Res. Public Health 2005, 2, 4-9.

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Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert