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Int. J. Environ. Res. Public Health 2016, 13(3), 321; doi:10.3390/ijerph13030321

An Evaluation of the Efficacy of Selective Alpha-Blockers in the Treatment of Children with Neurogenic Bladder Dysfunction—Preliminary Findings

1
Pediatric Surgery and Urology Department, Neurourology Unit, Poznań University of Medical Sciences, ul. Szpitalna 27/33, Poznań 60-572, Poland
2
Chair for Rheumatology and Rehabilitation, Poznań University of Medical Sciences, ul. 28 Czerwca 135/147, Poznań 61-545, Poland
3
Pediatric Nephrology Department, Poznań University of Medical Sciences, ul. Szpitalna 27/33, Poznań 60-572, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Received: 28 December 2015 / Revised: 24 February 2016 / Accepted: 29 February 2016 / Published: 15 March 2016
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Abstract

The aim of this study was to assess the usefulness of selective α1-blockers in children with neurogenic urinary tract dysfunctions and increased leak point pressure (LPP). 14 children from age 6 to 16 years with neurogenic urinary tract dysfunctions (neurogenic bladder) and LPP > 40 cm H2O were enrolled in the study. All patients received a selective α1-blocker (doxazosin) for 6–8 weeks with an initial dosage of 0.03 mg/kg. During the observation period the continuation of oral anticholinergics, Clean Intermittent Catheterization (CIC), observation of “urinary dryness” and urinary incontinence periods were recommended. Patients were scheduled for a follow-up visit and urodynamic investigation after 6–8 weeks after the doxazosin therapy was started. In 4 patients, urine leakage occurred at lower pressures; in 9 patients, no significant changes in urine leak point pressures were detected; in 3 patients, there was a significant increase in the bladder capacity; in one patient, deterioration in continence was noted. The differences both in LPP and LPV before and after the treatment were not statistically significant. Our observations are consistent with the conclusions from other studies and showed no evident efficacy of doxazosin in children with neurogenic bladder. View Full-Text
Keywords: neurogenic bladder dysfunction; alpha-blocker; doxazosin; sphincter; urodynamics neurogenic bladder dysfunction; alpha-blocker; doxazosin; sphincter; urodynamics
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kroll, P.; Gajewska, E.; Zachwieja, J.; Sobieska, M.; Mańkowski, P. An Evaluation of the Efficacy of Selective Alpha-Blockers in the Treatment of Children with Neurogenic Bladder Dysfunction—Preliminary Findings. Int. J. Environ. Res. Public Health 2016, 13, 321.

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