Mar. Drugs 2011, 9(8), 1368-1378; doi:10.3390/md9081368
Communication

Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium

Received: 1 June 2011; in revised form: 15 July 2011 / Accepted: 19 July 2011 / Published: 12 August 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: To investigate the structurally novel and bioactive natural compounds from marine-derived microorganisms under high salinity, the fungus Aspergillus terreus PT06-2 was isolated from the sediment of the Putian Sea Saltern, Fujian, China. Three new compounds, terremides A (1) and B (2) and terrelactone A (3), along with twelve known compounds (415) were isolated and identified from the fermentation broth of A. terreus PT06-2 at 10% salinity. Among these metabolites, compounds 4 and 15 only produced in the 10% salinity culture, were identified as methyl 3,4,5-trimethoxy-2-(2-(nicotinamido) benzamido) benzoate, and (+)-terrein, respectively. The new compounds 1 and 2 exhibited antibacterial activity against Pseudomonas aeruginosa and Enterobacter aerogenes with MIC values of 63.9 and 33.5 μM, respectively. Compounds 5 showed moderate anti-H1N1 activity and lower cytotoxicity with IC50 and CC50 values of and 143.1 and 976.4 μM, respectively.
Keywords: Aspergillus terreus; high salinity metabolites; terremides A and B; terrelactone A
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MDPI and ACS Style

Wang, Y.; Zheng, J.; Liu, P.; Wang, W.; Zhu, W. Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium. Mar. Drugs 2011, 9, 1368-1378.

AMA Style

Wang Y, Zheng J, Liu P, Wang W, Zhu W. Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium. Marine Drugs. 2011; 9(8):1368-1378.

Chicago/Turabian Style

Wang, Yi; Zheng, Jinkai; Liu, Peipei; Wang, Wei; Zhu, Weiming. 2011. "Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium." Mar. Drugs 9, no. 8: 1368-1378.

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