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• Zheng, J
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Mar. Drugs 2011, 9(8), 1368-1378; doi:10.3390/md9081368

Communication

Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium

Yi Wang ^† , Jinkai Zheng ^† , Peipei Liu, Wei Wang and Weiming Zhu*

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China ^† These authors contributed equally to this work.

* Author to whom correspondence should be addressed.

Received: 1 June 2011; in revised form: 15 July 2011 / Accepted: 19 July 2011 / Published: 12 August 2011

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Abstract: To investigate the structurally novel and bioactive natural compounds from marine-derived microorganisms under high salinity, the fungus Aspergillus terreus PT06-2 was isolated from the sediment of the Putian Sea Saltern, Fujian, China. Three new compounds, terremides A (1) and B (2) and terrelactone A (3), along with twelve known compounds (4–15) were isolated and identified from the fermentation broth of A. terreus PT06-2 at 10% salinity. Among these metabolites, compounds 4 and 15 only produced in the 10% salinity culture, were identified as methyl 3,4,5-trimethoxy-2-(2-(nicotinamido) benzamido) benzoate, and (+)-terrein, respectively. The new compounds 1 and 2 exhibited antibacterial activity against Pseudomonas aeruginosa and Enterobacter aerogenes with MIC values of 63.9 and 33.5 μM, respectively. Compounds 5 showed moderate anti-H1N1 activity and lower cytotoxicity with IC₅₀ and CC₅₀ values of and 143.1 and 976.4 μM, respectively.

Keywords: Aspergillus terreus; high salinity metabolites; terremides A and B; terrelactone A

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