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Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 1 June 2011; in revised form: 15 July 2011 / Accepted: 19 July 2011 / Published: 12 August 2011
Abstract: To investigate the structurally novel and bioactive natural compounds from marine-derived microorganisms under high salinity, the fungus Aspergillus terreus PT06-2 was isolated from the sediment of the Putian Sea Saltern, Fujian, China. Three new compounds, terremides A (1) and B (2) and terrelactone A (3), along with twelve known compounds (4–15) were isolated and identified from the fermentation broth of A. terreus PT06-2 at 10% salinity. Among these metabolites, compounds 4 and 15 only produced in the 10% salinity culture, were identified as methyl 3,4,5-trimethoxy-2-(2-(nicotinamido) benzamido) benzoate, and (+)-terrein, respectively. The new compounds 1 and 2 exhibited antibacterial activity against Pseudomonas aeruginosa and Enterobacter aerogenes with MIC values of 63.9 and 33.5 μM, respectively. Compounds 5 showed moderate anti-H1N1 activity and lower cytotoxicity with IC50 and CC50 values of and 143.1 and 976.4 μM, respectively.
Keywords: Aspergillus terreus; high salinity metabolites; terremides A and B; terrelactone A
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Wang, Y.; Zheng, J.; Liu, P.; Wang, W.; Zhu, W. Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium. Mar. Drugs 2011, 9, 1368-1378.
Wang Y, Zheng J, Liu P, Wang W, Zhu W. Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium. Marine Drugs. 2011; 9(8):1368-1378.
Wang, Yi; Zheng, Jinkai; Liu, Peipei; Wang, Wei; Zhu, Weiming. 2011. "Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium." Mar. Drugs 9, no. 8: 1368-1378.