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Mar. Drugs 2011, 9(12), 2809-2817; doi:10.3390/md9122809
Article

Aurantoside J: a New Tetramic Acid Glycoside from Theonella swinhoei. Insights into the Antifungal Potential of Aurantosides

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Received: 3 November 2011; in revised form: 7 December 2011 / Accepted: 15 December 2011 / Published: 20 December 2011
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Abstract: The chemical investigation of an Indonesian specimen of Theonella swinhoei afforded four aurantosides, one of which, aurantoside J (5), is a new compound. The structure of this metabolite, exhibiting the unprecedented N-α-glycosidic linkage between the pentose and the tetramate units, has been determined through detailed spectroscopic analysis. The four obtained aurantosides have been tested against five fungal strains (four Candida and one Fusarium) responsible of invasive infections in immuno-compromised patients. The non-cytotoxic aurantoside I (4) was the single compound to show an excellent potency against all the tested strains, thus providing valuable insights about the antifungal potential of this class of compounds and the structure-activity relationships.
Keywords: Theonella swhinoei; aurantosides; N-glycosides; antifungal activity Theonella swhinoei; aurantosides; N-glycosides; antifungal activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Angawi, R.F.; Bavestrello, G.; Calcinai, B.; Dien, H.A.; Donnarumma, G.; Tufano, M.A.; Paoletti, I.; Grimaldi, E.; Chianese, G.; Fattorusso, E.; Taglialatela-Scafati, O. Aurantoside J: a New Tetramic Acid Glycoside from Theonella swinhoei. Insights into the Antifungal Potential of Aurantosides. Mar. Drugs 2011, 9, 2809-2817.

AMA Style

Angawi RF, Bavestrello G, Calcinai B, Dien HA, Donnarumma G, Tufano MA, Paoletti I, Grimaldi E, Chianese G, Fattorusso E, Taglialatela-Scafati O. Aurantoside J: a New Tetramic Acid Glycoside from Theonella swinhoei. Insights into the Antifungal Potential of Aurantosides. Marine Drugs. 2011; 9(12):2809-2817.

Chicago/Turabian Style

Angawi, Rihab F.; Bavestrello, Giorgio; Calcinai, Barbara; Dien, Henny Adeleida; Donnarumma, Giovanna; Tufano, Maria Antonietta; Paoletti, Iole; Grimaldi, Elena; Chianese, Giuseppina; Fattorusso, Ernesto; Taglialatela-Scafati, Orazio. 2011. "Aurantoside J: a New Tetramic Acid Glycoside from Theonella swinhoei. Insights into the Antifungal Potential of Aurantosides." Mar. Drugs 9, no. 12: 2809-2817.



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