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Chitosan Modification and Pharmaceutical/Biomedical Applications
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China
School of Medicine and Pharmaceutics, Jiangnan University, Wuxi 214122, Jiangsu, China
School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China
Jiangsu Animal Husbandry and Veterinary College, Taizhou 225300, Jiangsu, China
School of Chemical Engineering, Jiangnan University, Wuxi 214122, China
* Authors to whom correspondence should be addressed.
Received: 20 April 2010; in revised form: 29 May 2010 / Accepted: 9 June 2010 / Published: 25 June 2010
Abstract: Chitosan has received much attention as a functional biopolymer for diverse applications, especially in pharmaceutics and medicine. Our recent efforts focused on the chemical and biological modification of chitosan in order to increase its solubility in aqueous solutions and absorbability in the in vivo system, thus for a better use of chitosan. This review summarizes chitosan modification and its pharmaceutical/biomedical applications based on our achievements as well as the domestic and overseas developments: (1) enzymatic preparation of low molecular weight chitosans/chitooligosaccharides with their hypocholesterolemic and immuno-modulating effects; (2) the effects of chitin, chitosan and their derivatives on blood hemostasis; and (3) synthesis of a non-toxic ion ligand—D-Glucosaminic acid from Oxidation of D-Glucosamine for cancer and diabetes therapy.
Keywords: chitosan derivatives; hypocholesterolemic; immunoenhancing; homeostasis; D-Glucosaminic Acid
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MDPI and ACS Style
Zhang, J.; Xia, W.; Liu, P.; Cheng, Q.; Tahi, T.; Gu, W.; Li, B. Chitosan Modification and Pharmaceutical/Biomedical Applications. Mar. Drugs 2010, 8, 1962-1987.
Zhang J, Xia W, Liu P, Cheng Q, Tahi T, Gu W, Li B. Chitosan Modification and Pharmaceutical/Biomedical Applications. Marine Drugs. 2010; 8(7):1962-1987.
Zhang, Jiali; Xia, Wenshui; Liu, Ping; Cheng, Qinyuan; Tahi, Talba; Gu, Wenxiu; Li, Bo. 2010. "Chitosan Modification and Pharmaceutical/Biomedical Applications." Mar. Drugs 8, no. 7: 1962-1987.