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Mar. Drugs 2010, 8(7), 1962-1987; doi:10.3390/md8071962

Chitosan Modification and Pharmaceutical/Biomedical Applications

1,2,* , 1,3,* , 4, 1,3, 1,3, 5 and 1,3
1 State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China 2 School of Medicine and Pharmaceutics, Jiangnan University, Wuxi 214122, Jiangsu, China 3 School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China 4 Jiangsu Animal Husbandry and Veterinary College, Taizhou 225300, Jiangsu, China 5 School of Chemical Engineering, Jiangnan University, Wuxi 214122, China
* Authors to whom correspondence should be addressed.
Received: 20 April 2010 / Revised: 29 May 2010 / Accepted: 9 June 2010 / Published: 25 June 2010
(This article belongs to the Special Issue Marine Chitin and Chitosan)
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Chitosan has received much attention as a functional biopolymer for diverse applications, especially in pharmaceutics and medicine. Our recent efforts focused on the chemical and biological modification of chitosan in order to increase its solubility in aqueous solutions and absorbability in the in vivo system, thus for a better use of chitosan. This review summarizes chitosan modification and its pharmaceutical/biomedical applications based on our achievements as well as the domestic and overseas developments: (1) enzymatic preparation of low molecular weight chitosans/chitooligosaccharides with their hypocholesterolemic and immuno-modulating effects; (2) the effects of chitin, chitosan and their derivatives on blood hemostasis; and (3) synthesis of a non-toxic ion ligand—D-Glucosaminic acid from Oxidation of D-Glucosamine for cancer and diabetes therapy.
Keywords: chitosan derivatives; hypocholesterolemic; immunoenhancing; homeostasis; D-Glucosaminic Acid chitosan derivatives; hypocholesterolemic; immunoenhancing; homeostasis; D-Glucosaminic Acid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, J.; Xia, W.; Liu, P.; Cheng, Q.; Tahi, T.; Gu, W.; Li, B. Chitosan Modification and Pharmaceutical/Biomedical Applications. Mar. Drugs 2010, 8, 1962-1987.

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