Mar. Drugs 2010, 8(4), 1469-1481; doi:10.3390/md8041469
Article

Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi

Jian-ye Zhang 1 email, Li-yang Tao 1 email, Yong-ju Liang 1 email, Li-ming Chen 1 email, Yan-jun Mi 1 email, Li-sheng Zheng 1 email, Fang Wang 1 email, Zhi-gang She 2,* email, Yong-cheng Lin 2 , Kenneth Kin Wah To 3 email and Li-wu Fu 1,* email
1 State Key Laboratory for Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, 510060, China 2 School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, 510275, China 3 School of Pharmacy, The Chinese University of Hong Kong, Hong Kong, China
* Authors to whom correspondence should be addressed.
Received: 12 March 2010; in revised form: 1 April 2010 / Accepted: 21 April 2010 / Published: 23 April 2010
PDF Full-text Download PDF Full-Text [525 KB, uploaded 23 April 2010 08:28 CEST]
Abstract: In this article, we report anticancer activity of 14 anthracenedione derivatives separated from the secondary metabolites of the mangrove endophytic fungi Halorosellinia sp. (No. 1403) and Guignardia sp. (No. 4382). Some of them inhibited potently the growth of KB and KBv200 cells, among which compound 6 displayed strong cytotoxicity with IC50 values of 3.17 and 3.21 μM to KB and KBv200 cells, respectively. Furthermore, we demonstrate that the mechanism involved in the apoptosis induced by compound 6 is probably related to mitochondrial dysfunction. Additionally, the structure-activity relationships of these compounds are discussed.
Keywords: mangrove endophytic fungi; anthracenedione derivatives; anticancer; apoptosis; structure-activity relationship

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Zhang, J.-Y.; Tao, L.-Y.; Liang, Y.-J.; Chen, L.-M.; Mi, Y.-J.; Zheng, L.-S.; Wang, F.; She, Z.-G.; Lin, Y.-C.; To, K.K.W.; Fu, L.-W. Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi. Mar. Drugs 2010, 8, 1469-1481.

AMA Style

Zhang J-Y, Tao L-Y, Liang Y-J, Chen L-M, Mi Y-J, Zheng L-S, Wang F, She Z-G, Lin Y-C, To KKW, Fu L-W. Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi. Marine Drugs. 2010; 8(4):1469-1481.

Chicago/Turabian Style

Zhang, Jian-ye; Tao, Li-yang; Liang, Yong-ju; Chen, Li-ming; Mi, Yan-jun; Zheng, Li-sheng; Wang, Fang; She, Zhi-gang; Lin, Yong-cheng; To, Kenneth Kin Wah; Fu, Li-wu. 2010. "Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi." Mar. Drugs 8, no. 4: 1469-1481.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert