Mar. Drugs 2010, 8(4), 1469-1481; doi:10.3390/md8041469
Article

Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi

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Received: 12 March 2010; in revised form: 1 April 2010 / Accepted: 21 April 2010 / Published: 23 April 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In this article, we report anticancer activity of 14 anthracenedione derivatives separated from the secondary metabolites of the mangrove endophytic fungi Halorosellinia sp. (No. 1403) and Guignardia sp. (No. 4382). Some of them inhibited potently the growth of KB and KBv200 cells, among which compound 6 displayed strong cytotoxicity with IC50 values of 3.17 and 3.21 μM to KB and KBv200 cells, respectively. Furthermore, we demonstrate that the mechanism involved in the apoptosis induced by compound 6 is probably related to mitochondrial dysfunction. Additionally, the structure-activity relationships of these compounds are discussed.
Keywords: mangrove endophytic fungi; anthracenedione derivatives; anticancer; apoptosis; structure-activity relationship
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MDPI and ACS Style

Zhang, J.-Y.; Tao, L.-Y.; Liang, Y.-J.; Chen, L.-M.; Mi, Y.-J.; Zheng, L.-S.; Wang, F.; She, Z.-G.; Lin, Y.-C.; To, K.K.W.; Fu, L.-W. Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi. Mar. Drugs 2010, 8, 1469-1481.

AMA Style

Zhang J-Y, Tao L-Y, Liang Y-J, Chen L-M, Mi Y-J, Zheng L-S, Wang F, She Z-G, Lin Y-C, To KKW, Fu L-W. Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi. Marine Drugs. 2010; 8(4):1469-1481.

Chicago/Turabian Style

Zhang, Jian-ye; Tao, Li-yang; Liang, Yong-ju; Chen, Li-ming; Mi, Yan-jun; Zheng, Li-sheng; Wang, Fang; She, Zhi-gang; Lin, Yong-cheng; To, Kenneth Kin Wah; Fu, Li-wu. 2010. "Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi." Mar. Drugs 8, no. 4: 1469-1481.


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