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Mar. Drugs 2010, 8(4), 1469-1481; doi:10.3390/md8041469
Article

Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi

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 and 1,*
1 State Key Laboratory for Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, 510060, China 2 School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, 510275, China 3 School of Pharmacy, The Chinese University of Hong Kong, Hong Kong, China
* Authors to whom correspondence should be addressed.
Received: 12 March 2010 / Revised: 1 April 2010 / Accepted: 21 April 2010 / Published: 23 April 2010
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Abstract

In this article, we report anticancer activity of 14 anthracenedione derivatives separated from the secondary metabolites of the mangrove endophytic fungi Halorosellinia sp. (No. 1403) and Guignardia sp. (No. 4382). Some of them inhibited potently the growth of KB and KBv200 cells, among which compound 6 displayed strong cytotoxicity with IC50 values of 3.17 and 3.21 μM to KB and KBv200 cells, respectively. Furthermore, we demonstrate that the mechanism involved in the apoptosis induced by compound 6 is probably related to mitochondrial dysfunction. Additionally, the structure-activity relationships of these compounds are discussed.
Keywords: mangrove endophytic fungi; anthracenedione derivatives; anticancer; apoptosis; structure-activity relationship mangrove endophytic fungi; anthracenedione derivatives; anticancer; apoptosis; structure-activity relationship
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, J.-Y.; Tao, L.-Y.; Liang, Y.-J.; Chen, L.-M.; Mi, Y.-J.; Zheng, L.-S.; Wang, F.; She, Z.-G.; Lin, Y.-C.; To, K.K.W.; Fu, L.-W. Anthracenedione Derivatives as Anticancer Agents Isolated from Secondary Metabolites of the Mangrove Endophytic Fungi. Mar. Drugs 2010, 8, 1469-1481.

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