Next Article in Journal
Bioprocessing Data for the Production of Marine Enzymes
Next Article in Special Issue
Production of Chitooligosaccharides and Their Potential Applications in Medicine
Previous Article in Journal
The Tropical Brown Alga Lobophora variegata: A Source of Antiprotozoal Compounds
Previous Article in Special Issue
Chitosan in Plant Protection
Article Menu

Export Article

Open AccessReview
Mar. Drugs 2010, 8(4), 1305-1322; doi:10.3390/md8041305

Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems

Department of Pharmaceutical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, 0001, South Africa
Received: 9 February 2010 / Revised: 17 March 2010 / Accepted: 22 March 2010 / Published: 19 April 2010
(This article belongs to the Special Issue Marine Chitin and Chitosan)
View Full-Text   |   Download PDF [385 KB, uploaded 24 February 2015]   |  

Abstract

Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. However, one drawback of using this natural polysaccharide in modified release dosage forms for oral administration is its fast dissolution rate in the stomach. Since chitosan is positively charged at low pH values (below its pKa value), it spontaneously associates with negatively charged polyions in solution to form polyelectrolyte complexes. These chitosan based polyelectrolyte complexes exhibit favourable physicochemical properties with preservation of chitosan’s biocompatible characteristics. These complexes are therefore good candidate excipient materials for the design of different types of dosage forms. It is the aim of this review to describe complexation of chitosan with selected natural and synthetic polyanions and to indicate some of the factors that influence the formation and stability of these polyelectrolyte complexes. Furthermore, recent investigations into the use of these complexes as excipients in drug delivery systems such as nano- and microparticles, beads, fibers, sponges and matrix type tablets are briefly described.
Keywords: chitosan; polyelectrolyte complex; self assembly; drug delivery; modified release chitosan; polyelectrolyte complex; self assembly; drug delivery; modified release
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Hamman, J.H. Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems. Mar. Drugs 2010, 8, 1305-1322.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top