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Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems
Department of Pharmaceutical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, 0001, South Africa
Received: 9 February 2010; in revised form: 17 March 2010 / Accepted: 22 March 2010 / Published: 19 April 2010
Abstract: Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. However, one drawback of using this natural polysaccharide in modified release dosage forms for oral administration is its fast dissolution rate in the stomach. Since chitosan is positively charged at low pH values (below its pKa value), it spontaneously associates with negatively charged polyions in solution to form polyelectrolyte complexes. These chitosan based polyelectrolyte complexes exhibit favourable physicochemical properties with preservation of chitosan’s biocompatible characteristics. These complexes are therefore good candidate excipient materials for the design of different types of dosage forms. It is the aim of this review to describe complexation of chitosan with selected natural and synthetic polyanions and to indicate some of the factors that influence the formation and stability of these polyelectrolyte complexes. Furthermore, recent investigations into the use of these complexes as excipients in drug delivery systems such as nano- and microparticles, beads, fibers, sponges and matrix type tablets are briefly described.
Keywords: chitosan; polyelectrolyte complex; self assembly; drug delivery; modified release
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Cite This Article
MDPI and ACS Style
Hamman, J.H. Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems. Mar. Drugs 2010, 8, 1305-1322.
Hamman JH. Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems. Marine Drugs. 2010; 8(4):1305-1322.
Hamman, Josias H. 2010. "Chitosan Based Polyelectrolyte Complexes as Potential Carrier Materials in Drug Delivery Systems." Mar. Drugs 8, no. 4: 1305-1322.