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Mar. Drugs 2010, 8(4), 1094-1105; doi:10.3390/md8041094

Anticancer Effect and Structure-Activity Analysis of Marine Products Isolated from Metabolites of Mangrove Fungi in the South China Sea

1
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-Sen University, Guangzhou, 510060, China
2
School of Pharmacy, The Chinese University of Hong Kong, Hong Kong, China
3
School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, 510275, China
*
Authors to whom correspondence should be addressed.
Received: 21 January 2010 / Revised: 22 March 2010 / Accepted: 30 March 2010 / Published: 1 April 2010
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Abstract

Marine-derived fungi provide plenty of structurally unique and biologically active secondary metabolites. We screened 87 marine products from mangrove fungi in the South China Sea for anticancer activity by MTT assay. 14% of the compounds (11/86) exhibited a potent activity against cancer in vitro. Importantly, some compounds such as compounds 78 and 81 appeared to be promising for treating cancer patients with multidrug resistance, which should encourage more efforts to isolate promising candidates for further development as clinically useful chemotherapeutic drugs. Furthermore, DNA intercalation was not involved in their anticancer activities, as determined by DNA binding assay. On the other hand, the structure-activity analysis indicated that the hydroxyl group was important for their cytotoxic activity and that bulky functional groups such as phenyl rings could result in a loss of biological activity, which will direct the further development of marine product-based derivatives. View Full-Text
Keywords: mangrove fungi; multidrug resistance (MDR); quinones; xyloketal; isoflavone; prostaglandins mangrove fungi; multidrug resistance (MDR); quinones; xyloketal; isoflavone; prostaglandins
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Tao, L.-Y.; Zhang, J.-Y.; Liang, Y.-J.; Chen, L.-M.; Zheng, L.-S.; Wang, F.; Mi, Y.-J.; She, Z.-G.; To, K.K.W.; Lin, Y.-C.; Fu, L.-W. Anticancer Effect and Structure-Activity Analysis of Marine Products Isolated from Metabolites of Mangrove Fungi in the South China Sea. Mar. Drugs 2010, 8, 1094-1105.

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