Mar. Drugs 2010, 8(2), 285-291; doi:10.3390/md8020285
Article

Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii

Anna Aiello 1 email, Ernesto Fattorusso 1 email, Concetta Imperatore 1 email, Marialuisa Menna 1,* email and Werner E.G. Müller 2 email
1 Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy 2 Department for Applied Molecular Biology, Institute for Physiological Chemistry, Johannes Gutenberg-University Medical Center, Duesbergweg 6, D-55099 Mainz, Germany
* Author to whom correspondence should be addressed.
Received: 22 January 2010; in revised form: 28 January 2010 / Accepted: 9 February 2010 / Published: 21 February 2010
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Abstract: Chemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosine-iodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of the new compound 1 has been assigned on the basis of spectroscopic analysis.Both compounds were tested for cytotoxicity in vitro against two different cancer cell lines, L5178Y (mouse lymphoma) and PC-12 (rat pheochromocytoma). Iodocionin was shown to possess significant and selective activity against lymphoma cells with an IC50 of 7.75 μg/mL.
Keywords: natural products; iodinated metabolites; cytotoxic activity; structure elucidation

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MDPI and ACS Style

Aiello, A.; Fattorusso, E.; Imperatore, C.; Menna, M.; Müller, W.E. Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii. Mar. Drugs 2010, 8, 285-291.

AMA Style

Aiello A, Fattorusso E, Imperatore C, Menna M, Müller WE. Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii. Marine Drugs. 2010; 8(2):285-291.

Chicago/Turabian Style

Aiello, Anna; Fattorusso, Ernesto; Imperatore, Concetta; Menna, Marialuisa; Müller, Werner E. 2010. "Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii." Mar. Drugs 8, no. 2: 285-291.

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