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Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy
Department for Applied Molecular Biology, Institute for Physiological Chemistry, Johannes Gutenberg-University Medical Center, Duesbergweg 6, D-55099 Mainz, Germany
* Author to whom correspondence should be addressed.
Received: 22 January 2010; in revised form: 28 January 2010 / Accepted: 9 February 2010 / Published: 21 February 2010
Abstract: Chemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosine-iodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of the new compound 1 has been assigned on the basis of spectroscopic analysis.Both compounds were tested for cytotoxicity in vitro against two different cancer cell lines, L5178Y (mouse lymphoma) and PC-12 (rat pheochromocytoma). Iodocionin was shown to possess significant and selective activity against lymphoma cells with an IC50 of 7.75 μg/mL.
Keywords: natural products; iodinated metabolites; cytotoxic activity; structure elucidation
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Aiello, A.; Fattorusso, E.; Imperatore, C.; Menna, M.; Müller, W.E. Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii. Mar. Drugs 2010, 8, 285-291.
Aiello A, Fattorusso E, Imperatore C, Menna M, Müller WE. Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii. Marine Drugs. 2010; 8(2):285-291.
Aiello, Anna; Fattorusso, Ernesto; Imperatore, Concetta; Menna, Marialuisa; Müller, Werner E. 2010. "Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii." Mar. Drugs 8, no. 2: 285-291.