Next Article in Journal
Bioactive Sesterterpenes and Triterpenes from Marine Sponges: Occurrence and Pharmacological Significance
Previous Article in Journal
Chitins and Chitosans as Immunoadjuvants and Non-Allergenic Drug Carriers
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2010, 8(2), 285-291; doi:10.3390/md8020285

Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii

1
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy
2
Department for Applied Molecular Biology, Institute for Physiological Chemistry, Johannes Gutenberg-University Medical Center, Duesbergweg 6, D-55099 Mainz, Germany
*
Author to whom correspondence should be addressed.
Received: 22 January 2010 / Revised: 28 January 2010 / Accepted: 9 February 2010 / Published: 21 February 2010
View Full-Text   |   Download PDF [203 KB, uploaded 24 February 2015]   |  

Abstract

Chemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosine-iodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of the new compound 1 has been assigned on the basis of spectroscopic analysis.Both compounds were tested for cytotoxicity in vitro against two different cancer cell lines, L5178Y (mouse lymphoma) and PC-12 (rat pheochromocytoma). Iodocionin was shown to possess significant and selective activity against lymphoma cells with an IC50 of 7.75 μg/mL.
Keywords: natural products; iodinated metabolites; cytotoxic activity; structure elucidation natural products; iodinated metabolites; cytotoxic activity; structure elucidation
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Aiello, A.; Fattorusso, E.; Imperatore, C.; Menna, M.; Müller, W.E. Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii. Mar. Drugs 2010, 8, 285-291.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top