Next Article in Journal
Bioactive Sesterterpenes and Triterpenes from Marine Sponges: Occurrence and Pharmacological Significance
Previous Article in Journal
Chitins and Chitosans as Immunoadjuvants and Non-Allergenic Drug Carriers
Mar. Drugs 2010, 8(2), 285-291; doi:10.3390/md8020285
Article

Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii

1
,
1
,
1
,
1,*  and 2
1 Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli “Federico II”, Via D. Montesano 49, 80131, Napoli, Italy 2 Department for Applied Molecular Biology, Institute for Physiological Chemistry, Johannes Gutenberg-University Medical Center, Duesbergweg 6, D-55099 Mainz, Germany
* Author to whom correspondence should be addressed.
Received: 22 January 2010 / Revised: 28 January 2010 / Accepted: 9 February 2010 / Published: 21 February 2010
View Full-Text   |   Download PDF [203 KB, uploaded 24 February 2015]   |  

Abstract

Chemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosine-iodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of the new compound 1 has been assigned on the basis of spectroscopic analysis.Both compounds were tested for cytotoxicity in vitro against two different cancer cell lines, L5178Y (mouse lymphoma) and PC-12 (rat pheochromocytoma). Iodocionin was shown to possess significant and selective activity against lymphoma cells with an IC50 of 7.75 μg/mL.
Keywords: natural products; iodinated metabolites; cytotoxic activity; structure elucidation natural products; iodinated metabolites; cytotoxic activity; structure elucidation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Aiello, A.; Fattorusso, E.; Imperatore, C.; Menna, M.; Müller, W.E. Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii. Mar. Drugs 2010, 8, 285-291.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert