Mar. Drugs 2010, 8(2), 285-291; doi:10.3390/md8020285
Article

Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii

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Received: 22 January 2010; in revised form: 28 January 2010 / Accepted: 9 February 2010 / Published: 21 February 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Chemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosine-iodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of the new compound 1 has been assigned on the basis of spectroscopic analysis.Both compounds were tested for cytotoxicity in vitro against two different cancer cell lines, L5178Y (mouse lymphoma) and PC-12 (rat pheochromocytoma). Iodocionin was shown to possess significant and selective activity against lymphoma cells with an IC50 of 7.75 μg/mL.
Keywords: natural products; iodinated metabolites; cytotoxic activity; structure elucidation
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MDPI and ACS Style

Aiello, A.; Fattorusso, E.; Imperatore, C.; Menna, M.; Müller, W.E. Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii. Mar. Drugs 2010, 8, 285-291.

AMA Style

Aiello A, Fattorusso E, Imperatore C, Menna M, Müller WE. Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii. Marine Drugs. 2010; 8(2):285-291.

Chicago/Turabian Style

Aiello, Anna; Fattorusso, Ernesto; Imperatore, Concetta; Menna, Marialuisa; Müller, Werner E. 2010. "Iodocionin, a Cytotoxic Iodinated Metabolite from the Mediterranean Ascidian Ciona edwardsii." Mar. Drugs 8, no. 2: 285-291.


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