Mar. Drugs 2010, 8(10), 2721-2732; doi:10.3390/md8102721

Toxic Effects of Domoic Acid in the Seabream Sparus aurata

1email, 1,2email, 1email, 3email, 1email, 1,4email, 3email, 3email and 1,5,* email
Received: 8 September 2010; in revised form: 7 October 2010 / Accepted: 14 October 2010 / Published: 15 October 2010
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Neurotoxicity induced in fish by domoic acid (DA) was assessed with respect to occurrence of neurotoxic signs, lethality, and histopathology by light microscopy. Sparus aurata were exposed to a single dose of DA by intraperitoneal (i.p.) injection of 0, 0.45, 0.9, and 9.0 mg DA kg−1 bw. Mortality (66.67 ± 16.67%) was only observed in dose of 9.0 mg kg−1 bw. Signs of neurological toxicity were detected for the doses of 0.9 and 9.0 mg DA kg−1 bw. Furthermore, the mean concentrations (±SD) of DA detected by HPLC-UV in extracts of brain after exposure to 9.0 mg DA kg−1 bw were 0.61 ± 0.01, 0.96 ± 0.00, and 0.36 ± 0.01 mg DA kg−1 tissue at 1, 2, and 4 hours. The lack of major permanent brain damage in S. aurata, and reversibility of neurotoxic signs, suggest that lower susceptibility to DA or neuronal recovery occurs in affected individuals.
Keywords: domoic acid; amnesic shellfish poisoning; Pseudo-nitzschia; algal neurotoxin; Sparus aurata
PDF Full-text Download PDF Full-Text [404 KB, uploaded 15 October 2010 15:14 CEST]

Export to BibTeX |

MDPI and ACS Style

Nogueira, I.; Lobo-da-Cunha, A.; Afonso, A.; Rivera, S.; Azevedo, J.; Monteiro, R.; Cervantes, R.; Gago-Martinez, A.; Vasconcelos, V. Toxic Effects of Domoic Acid in the Seabream Sparus aurata. Mar. Drugs 2010, 8, 2721-2732.

AMA Style

Nogueira I, Lobo-da-Cunha A, Afonso A, Rivera S, Azevedo J, Monteiro R, Cervantes R, Gago-Martinez A, Vasconcelos V. Toxic Effects of Domoic Acid in the Seabream Sparus aurata. Marine Drugs. 2010; 8(10):2721-2732.

Chicago/Turabian Style

Nogueira, Isabel; Lobo-da-Cunha, Alexandre; Afonso, António; Rivera, Socorro; Azevedo, Joana; Monteiro, Rogério; Cervantes, Rosa; Gago-Martinez, Ana; Vasconcelos, Vítor. 2010. "Toxic Effects of Domoic Acid in the Seabream Sparus aurata." Mar. Drugs 8, no. 10: 2721-2732.

Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert