Mar. Drugs 2010, 8(10), 2659-2672; doi:10.3390/md8102659
Article

Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes

1 Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway 2 Proteomic Unit at the University of Bergen, Jonas Lies vei 91, 5009 Bergen, Norway 3 Department of Food and Environmental Sciences, University of Helsinki, P. O. Box 56, 00014 Helsinki, Finland 4 Translational Signalling group, Haukeland Univ. Hospital, Jonas Lies vei 91, 5009 Bergen, Norway
* Author to whom correspondence should be addressed.
Received: 31 August 2010; in revised form: 6 October 2010 / Accepted: 12 October 2010 / Published: 14 October 2010
(This article belongs to the Special Issue Marine Drugs as Antitumour Agents)
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Abstract: The potential of marine benthic cyanobacteria as a source of anticancer drug candidates was assessed in a screen for induction of cell death (apoptosis) in acute myeloid leukemia (AML) cells. Of the 41 marine cyanobacterial strains screened, more than half contained cell death-inducing activity. Several strains contained activity against AML cells, but not against non-malignant cells like hepatocytes and cardiomyoblasts. The apoptotic cell death induced by the various strains could be distinguished by the role of caspase activation and sensitivity to the recently detected chemotherapy-resistance-associated prosurvival protein LEDGF/p75. One strain (M44) was particularly promising since its activity counteracted the protective effect of LEDGF/p75 overexpressed in AML cells, acted synergistically with the anthracycline anticancer drug daunorubicin in AML cells, and protected cardiomyoblasts against the toxic effect of anthracyclines. We conclude that culturable benthic marine cyanobacteria from temperate environments provide a promising and hitherto underexploited source for novel antileukemic drugs.
Keywords: AML; cyanobacteria; apoptosis; cancer; leukemia

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MDPI and ACS Style

Oftedal, L.; Selheim, F.; Wahlsten, M.; Sivonen, K.; Døskeland, S.O.; Herfindal, L. Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes. Mar. Drugs 2010, 8, 2659-2672.

AMA Style

Oftedal L, Selheim F, Wahlsten M, Sivonen K, Døskeland SO, Herfindal L. Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes. Marine Drugs. 2010; 8(10):2659-2672.

Chicago/Turabian Style

Oftedal, Linn; Selheim, Frode; Wahlsten, Matti; Sivonen, Kaarina; Døskeland, Stein Ove; Herfindal, Lars. 2010. "Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not Cardiomyocytes." Mar. Drugs 8, no. 10: 2659-2672.

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