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Mar. Drugs 2010, 8(10), 2639-2646; doi:10.3390/md8102639
Article

Excavatoids O and P, New 12-Hydroxybriaranes from the Octocoral Briareum excavatum

1,2,3,4,5,* , 1,2
, 2,4
, 2
, 2,6
, 2
, 4,5,6
, 2
, 1,2
, 1,2
, 1,2
, 3
 and 7
1 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 2 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 3 Department of Life Science and the Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan 4 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 5 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 6 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, Taiwan 7 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
* Author to whom correspondence should be addressed.
Received: 7 September 2010 / Revised: 23 September 2010 / Accepted: 9 October 2010 / Published: 12 October 2010
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Abstract

Two new 12-hydroxybriarane diterpenoids, designated as excavatoids O (1) and P (2), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1 and 2 were established on the basis of extensive spectral data analysis. Excavatoid P (2) is the first metabolite which possesses a 6b-chlorine atom in briarane analogues.
Keywords: excavatoid; briarane; octocoral; Briareum excavatum excavatoid; briarane; octocoral; Briareum excavatum
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sung, P.-J.; Li, G.-Y.; Su, Y.-D.; Lin, M.-R.; Chang, Y.-C.; Kung, T.-H.; Lin, C.-S.; Chen, Y.-H.; Su, J.-H.; Lu, M.-C.; Kuo, J.; Weng, C.-F.; Hwang, T.-L. Excavatoids O and P, New 12-Hydroxybriaranes from the Octocoral Briareum excavatum. Mar. Drugs 2010, 8, 2639-2646.

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