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Mar. Drugs 2010, 8(10), 2639-2646; doi:10.3390/md8102639
Article

Excavatoids O and P, New 12-Hydroxybriaranes from the Octocoral Briareum excavatum

1,2,3,4,5,* , 1,2
,
2,4
,
2
,
2,6
,
2
,
4,5,6
,
2
,
1,2
,
1,2
,
1,2
,
3
 and
7
1 Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan 2 National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan 3 Department of Life Science and the Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan 4 Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan 5 Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan 6 Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University, Kaohsiung 804, Taiwan 7 Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
* Author to whom correspondence should be addressed.
Received: 7 September 2010 / Revised: 23 September 2010 / Accepted: 9 October 2010 / Published: 12 October 2010
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Abstract

Two new 12-hydroxybriarane diterpenoids, designated as excavatoids O (1) and P (2), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1 and 2 were established on the basis of extensive spectral data analysis. Excavatoid P (2) is the first metabolite which possesses a 6b-chlorine atom in briarane analogues.
Keywords: excavatoid; briarane; octocoral; Briareum excavatum excavatoid; briarane; octocoral; Briareum excavatum
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Sung, P.-J.; Li, G.-Y.; Su, Y.-D.; Lin, M.-R.; Chang, Y.-C.; Kung, T.-H.; Lin, C.-S.; Chen, Y.-H.; Su, J.-H.; Lu, M.-C.; Kuo, J.; Weng, C.-F.; Hwang, T.-L. Excavatoids O and P, New 12-Hydroxybriaranes from the Octocoral Briareum excavatum. Mar. Drugs 2010, 8, 2639-2646.

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