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Mar. Drugs 2008, 6(4), 578-586; doi:10.3390/md6040578
Article

Acetylcholinesterase-Inhibiting Activity of Pyrrole Derivatives from a Novel Marine Gliding Bacterium, Rapidithrix thailandica

1, 2, 2, 1,4, 3,4, 2,4,*  and 4
Received: 2 September 2008 / Revised: 3 October 2008 / Accepted: 8 October 2008 / Published: 13 October 2008
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Abstract

Acetylcholinesterase-inhibiting activity of marinoquinoline A (1), a new pyrroloquinoline from a novel species of a marine gliding bacterium Rapidithrix thailandica, was assessed (IC50 4.9 μM). Two related pyrrole derivatives, 3-(2'-aminophenyl)-pyrrole (3) and 2,2-dimethyl-pyrrolo-1,2-dihydroquinoline (4), were also isolated from two other strains of R. thailandica. The isolation of 3 from a natural source is reported here for the first time. Compound 4 was proposed to be an isolation artifact derived from 3. The two isolated compounds were virtually inactive in the acetylcholinesterase-inhibitory assay (enzyme inhibition < 30% at 0.1 g L-1).
Keywords: pyrroloquinolines; phenylpyrroles; gliding bacteria; Rapidithrix thailandica; acetylcholinesterase inhibitors pyrroloquinolines; phenylpyrroles; gliding bacteria; Rapidithrix thailandica; acetylcholinesterase inhibitors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sangnoi, Y.; Sakulkeo, O.; Yuenyongsawad, S.; Kanjana-opas, A.; Ingkaninan, K.; Plubrukarn, A.; Suwanborirux, K. Acetylcholinesterase-Inhibiting Activity of Pyrrole Derivatives from a Novel Marine Gliding Bacterium, Rapidithrix thailandica. Mar. Drugs 2008, 6, 578-586.

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