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Mar. Drugs 2007, 5(4), 151-156; doi:10.3390/md504151
Article

A Sesquiterpene Quinone, 5-Epi-smenospongine, Promotes TNF-α Production in LPS-stimulated RAW 264.7 Cells

1,* , 2, 2, 2 and 1
Received: 25 September 2007 / Accepted: 29 September 2007 / Published: 30 October 2007
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Abstract

Eight sesquiterpene quinones: ilimaquinone (1), smenospongidine (3),smenospongiarine (5), smenospongine (7), and their corresponding 5-epimers 2, 4, 6, and 8,isolated from the Palauan marine sponge Hippospongia sp., were examined regarding theireffects on TNF-α production in LPS-stimulated RAW 264.7 cells. 5-Epi-smenospongine(8) promoted the production of TNF-α to a level three times greater than the control at10 μM, but compounds 1-7 did not show apparent activity. The results suggest that thecis-decaline ring and a primary amine in the benzoquinone ring are necessary for activity.This is the first study to report the modulation of TNF-α production by a sesquiterpenequinone.
Keywords: Sesquiterpene quinone; marine sponge; Hippospongia sp.; TNF-α production; RAW 264.7 cells Sesquiterpene quinone; marine sponge; Hippospongia sp.; TNF-α production; RAW 264.7 cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Oda, T.; Wang, W.; Ukai, K.; Nakazawa, T.; Mochizuki, M. A Sesquiterpene Quinone, 5-Epi-smenospongine, Promotes TNF-α Production in LPS-stimulated RAW 264.7 Cells. Mar. Drugs 2007, 5, 151-156.

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