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Mar. Drugs 2005, 3(1), 1-8; doi:10.3390/md301001
Article

Amphidinolides B4 and B5, Potent Cytotoxic 26-Membered Macrolides from Dinoflagellate Amphidinium Species

1, 1, 1, 2, 2 and 1,*
1 Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan 2 Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan
* Author to whom correspondence should be addressed.
Received: 6 January 2005 / Accepted: 19 February 2005 / Published: 1 March 2005
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Abstract

Two new cytotoxic 26-membered macrolides, amphidinolides B4 (1) and B5 (2), have been isolated from a marine dinoflagellate Amphidinium sp. (strain Y-100), and the structures were elucidated on the basis of detailed analyses of 2D NMR data including 13C−13C correlations.
Keywords: dinoflagellate; Amphidinium sp.; amphidinolides B4 and B5; cytotoxic dinoflagellate; Amphidinium sp.; amphidinolides B4 and B5; cytotoxic
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Tsuda, M.; Kariya, Y.; Iwamoto, R.; Fukushi, E.; Kawabata, J.; Kobayashi, J. Amphidinolides B4 and B5, Potent Cytotoxic 26-Membered Macrolides from Dinoflagellate Amphidinium Species. Mar. Drugs 2005, 3, 1-8.

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