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Mar. Drugs 2004, 2(1), 1-7; doi:10.3390/md201001
Article

An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene-15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity

1, 2, 3 and 1,*
1 Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677-1848, USA 2 Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt 3 Laboratory of Pharmaceutical Sciences of Natural Resources, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan
* Author to whom correspondence should be addressed.
Received: 29 October 2003 / Accepted: 20 November 2003 / Published: 25 February 2004
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Abstract

An effective method for the synthesis of 7,8-epoxy-1,3,11-cembratriene-15R(α), 16-diol and its in vitro Epstein-Barr Virus Early Antigen (EBV-EA) Activation Chemopreventive Assay are reported. This semisynthetic product is a new cembranoid with a potent tumor inhibitory activity that is expected to be a lead compound for a new class of chemopreventive agents of marine origin.
Keywords: cancer chemoprevention; cembranoids; sarcophine; sarcophytol A; EBV-EA activation cancer chemoprevention; cembranoids; sarcophine; sarcophytol A; EBV-EA activation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Fahmy, H.; Khalifa, S.I.; Konoshima, T.; Zjawiony, J.K. An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene-15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity. Mar. Drugs 2004, 2, 1-7.

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