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Mar. Drugs 2004, 2(1), 1-7; doi:10.3390/md201001
Article

An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene-15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity

1, 2, 3 and 1,*
1 Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677-1848, USA 2 Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt 3 Laboratory of Pharmaceutical Sciences of Natural Resources, Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan
* Author to whom correspondence should be addressed.
Received: 29 October 2003 / Accepted: 20 November 2003 / Published: 25 February 2004
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Abstract

An effective method for the synthesis of 7,8-epoxy-1,3,11-cembratriene-15R(α), 16-diol and its in vitro Epstein-Barr Virus Early Antigen (EBV-EA) Activation Chemopreventive Assay are reported. This semisynthetic product is a new cembranoid with a potent tumor inhibitory activity that is expected to be a lead compound for a new class of chemopreventive agents of marine origin.
Keywords: cancer chemoprevention; cembranoids; sarcophine; sarcophytol A; EBV-EA activation cancer chemoprevention; cembranoids; sarcophine; sarcophytol A; EBV-EA activation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Fahmy, H.; Khalifa, S.I.; Konoshima, T.; Zjawiony, J.K. An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene-15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity. Mar. Drugs 2004, 2, 1-7.

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