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Peer-Review Record

Dimeric 1,4-Benzoquinone Derivatives with Cytotoxic Activities from the Marine-Derived Fungus Penicillium sp. L129

Mar. Drugs 2019, 17(7), 383; https://doi.org/10.3390/md17070383
by Hui-Min Zhang 1, Chuan-Xia Ju 1, Gang Li 1, Yong Sun 2, Yu Peng 1, Ying-Xia Li 1, Xiao-Ping Peng 1,* and Hong-Xiang Lou 1,2,*
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Mar. Drugs 2019, 17(7), 383; https://doi.org/10.3390/md17070383
Submission received: 12 June 2019 / Revised: 21 June 2019 / Accepted: 24 June 2019 / Published: 26 June 2019

Round  1

Reviewer 1 Report

Please find my comments about the results and the presentation below:

·         Table 3: Do the C8 and C9 protons really give a triplet? Maybe there is a dd?

·         Table 3: Why does not at least one C15 proton coupled to the C14 proton?

·         Table 5: The name of pathogens should be written with capital letter.


Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

Two new dimeric 1,4-benzoquinone derivatives, peniquinone A and peniquinone B  a new dibenzofuran penizofuran A  and a new pyrazinoquinazoline derivative quinadoline known  were isolated from a marine-derived fungus 16 Penicillium sp. L129 and characterized. This work is very good and should be published.

However there are few things to add - Figure1 proper description should be given for compound number 17

HPLC data for the compounds isloated should be incorporated in the SI

Author Response

Please see the attachment

Author Response File: Author Response.pdf

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