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Mar. Drugs 2018, 16(8), 282; https://doi.org/10.3390/md16080282

New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164

1
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266003, China
3
Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Nanning 530006, China
4
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China
5
Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
These authors contributed equally to this paper.
*
Authors to whom correspondence should be addressed.
Received: 22 July 2018 / Revised: 7 August 2018 / Accepted: 12 August 2018 / Published: 15 August 2018
(This article belongs to the Special Issue Marine Bacteria as Sources of Bioactive Compounds)
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Abstract

Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey’s method. Compound 1 exhibited cytotoxic effects on A549 and K562 cell lines with IC50 values of 15 and 23 μM, respectively. View Full-Text
Keywords: deep-sea-derived bacterium; Ochrobactrum sp.; ansamycins; trienomycins; cytotoxic activity deep-sea-derived bacterium; Ochrobactrum sp.; ansamycins; trienomycins; cytotoxic activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Fan, Y.; Wang, C.; Wang, L.; Chairoungdua, A.; Piyachaturawat, P.; Fu, P.; Zhu, W. New Ansamycins from the Deep-Sea-Derived Bacterium Ochrobactrum sp. OUCMDZ-2164. Mar. Drugs 2018, 16, 282.

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