Next Article in Journal
The Protective Effects of Clams on Hypercholesterolemia in Late-Stage Triple-Transgenic Alzheimer’s Diseased Mice Hearts
Previous Article in Journal
Antitumor Activity of Quinazolinone Alkaloids Inspired by Marine Natural Products
Previous Article in Special Issue
Intraocular Penetration of a vNAR: In Vivo and In Vitro VEGF165 Neutralization
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2018, 16(8), 262; https://doi.org/10.3390/md16080262

A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells

1
Department of Oral Biology, BK21 PLUS, Yonsei University College of Dentistry, Seoul 03722, Korea
2
Department of Global Medical Science, Yonsei University Wonju College of Medicine, Wonju 26426, Korea
3
Anti-Aging Research Institute of BIO-FD&C Co. Ltd., Incheon 21990, Korea
*
Authors to whom correspondence should be addressed.
Received: 11 July 2018 / Revised: 23 July 2018 / Accepted: 27 July 2018 / Published: 1 August 2018
(This article belongs to the Special Issue The Pharmacological Potential of Marine-Derived Peptides and Proteins)
View Full-Text   |   Download PDF [1905 KB, uploaded 1 August 2018]   |  

Abstract

Nicotinamide (NA), a water-soluble vitamin B3, has been shown to exert cellular-protective effects against reactive oxygen species (ROS). In order to improve the cellular-protective effects of NA, we synthesized a novel compound, nicotinyl–isoleucine–valine–histidine (NA–IVH), by combining NA with jellyfish peptides’ IVH. In the present study, we examined the cellular-protective effects of the novel synthetic nicotinyl-peptide, NA–IVH. We found that NA–IVH enhances the radical scavenging activity with a robust increase of the nuclear factor (erythroid-derived 2)-like factor (Nrf2) expression in human HaCaT keratinocytes. In addition, NA–IVH protected the cells from hydrogen peroxide (H2O2)-induced cell death. Interestingly, NA–IVH exhibited an improved wound-healing effect in a high glucose condition, possibly through the regulation of reactive oxygen species (ROS). Collectively, our results imply that a novel nicotinyl-peptide, NA–IVH, has a wound-healing effect in a hyperglycemic condition, possibly by modulating excessive ROS. View Full-Text
Keywords: nicotinamide; isoleucine-valine-histidine; antioxidant; nuclear factor (erythroid-derived 2)-like factor; wound-healing nicotinamide; isoleucine-valine-histidine; antioxidant; nuclear factor (erythroid-derived 2)-like factor; wound-healing
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Son, D.H.; Yang, D.J.; Sun, J.S.; Kim, S.K.; Kang, N.; Kang, J.Y.; Choi, Y.-H.; Lee, J.H.; Moh, S.H.; Shin, D.M.; Kim, K.W. A Novel Peptide, Nicotinyl–Isoleucine–Valine–Histidine (NA–IVH), Promotes Antioxidant Gene Expression and Wound Healing in HaCaT Cells. Mar. Drugs 2018, 16, 262.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top