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Mar. Drugs 2018, 16(6), 187; https://doi.org/10.3390/md16060187

Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram-Negative Bacterium Aequorivita sp.

1
GEOMAR Centre for Marine Biotechnology (GEOMAR-Biotech), Research Unit Marine Natural Products Chemistry, GEOMAR Helmholtz Centre for Ocean Research Kiel, Am Kiel-Kanal 44, 24106 Kiel, Germany
2
Institute of Protein Biochemistry, National Research Council, Via P. Castellino, 111, I-80131 Naples, Italy
3
Hoekmine BV, 3584 CS Utrecht, The Netherlands
4
Faculty of Mathematics and Natural Sciences, Kiel University, Christian-Albrechts-Platz 4, 24118 Kiel, Germany
*
Author to whom correspondence should be addressed.
Received: 15 May 2018 / Revised: 22 May 2018 / Accepted: 25 May 2018 / Published: 28 May 2018
(This article belongs to the Special Issue Marine Antimicrobial Agents)
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Abstract

The combination of LC-MS/MS based metabolomics approach and anti-MRSA activity-guided fractionation scheme was applied on the Gram-negative bacterium Aequorivita sp. isolated from shallow Antarctic sea sediment using a miniaturized culture chip technique. This methodology afforded the isolation of three new (13) and four known (47) N-terminal glycine- or serine-bearing iso-fatty acid amides esterified with another iso-fatty acid through their C-3 hydroxy groups. The chemical structures of the new compounds were elucidated using a set of spectroscopic (NMR, [α]D and FT-IR) and spectrometric (HRMS, HRMS/MS) methods. The aminolipids possessing an N-terminal glycine unit (1, 2, 4, 5) showed moderate in vitro antimicrobial activity against MRSA (IC50 values 22–145 μg/mL). This is the first in-depth chemistry and biological activity study performed on the microbial genus Aequorivita. View Full-Text
Keywords: Aequorivita; Gram-negative bacterium; miniaturized culture chip; linear aminolipid; MRSA; LC-MS/MS Aequorivita; Gram-negative bacterium; miniaturized culture chip; linear aminolipid; MRSA; LC-MS/MS
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chianese, G.; Esposito, F.P.; Parrot, D.; Ingham, C.; de Pascale, D.; Tasdemir, D. Linear Aminolipids with Moderate Antimicrobial Activity from the Antarctic Gram-Negative Bacterium Aequorivita sp.. Mar. Drugs 2018, 16, 187.

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