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Mar. Drugs 2017, 15(6), 169; doi:10.3390/md15060169

Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus

Faculty of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1142, Japan
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Received: 10 May 2017 / Revised: 6 June 2017 / Accepted: 6 June 2017 / Published: 9 June 2017
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Abstract

Trichodermanins C–E (13), new diterpenes with a rare fused 6-5-6-6 ring system, have been isolated from a fungus Trichoderma harzianum OUPS-111D-4 separated from a piece of a marine sponge Halichondria okadai, and these chemical structures have been established by spectroscopic analyses using IR, MASS, HRFABMS, and NMR spectra. We established their absolute stereostructures by application of the modified Mosher’s method. In addition, 1 inhibited the growth of cancer cell lines potently. View Full-Text
Keywords: trichodermanins; Trichoderma harzianum; marine microorganism; Halichondria okadai; diterpenes; 6-5-6-6 ring system; cytotoxicity trichodermanins; Trichoderma harzianum; marine microorganism; Halichondria okadai; diterpenes; 6-5-6-6 ring system; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Yamada, T.; Suzue, M.; Arai, T.; Kikuchi, T.; Tanaka, R. Trichodermanins C–E, New Diterpenes with a Fused 6-5-6-6 Ring System Produced by a Marine Sponge-Derived Fungus. Mar. Drugs 2017, 15, 169.

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