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Mar. Drugs 2017, 15(5), 136; doi:10.3390/md15050136

Transcriptomic Profiling of the Allorecognition Response to Grafting in the Demosponge Amphimedon queenslandica

School of Biological Sciences, University of Queensland, Brisbane QLD 4072, Australia
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Author to whom correspondence should be addressed.
Academic Editors: Allen Place and Paul Long
Received: 30 March 2017 / Revised: 3 May 2017 / Accepted: 5 May 2017 / Published: 11 May 2017
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology II 2016)
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Abstract

Sponges, despite their simple body plan, discriminate between self and nonself with remarkable specificity. Sponge grafting experiments simulate the effects of natural self or nonself contact under laboratory conditions. Here we take a transcriptomic approach to investigate the temporal response to self and nonself grafts in the marine demosponge Amphimedon queenslandica. Auto- and allografts were established, observed and sampled over a period of three days, over which time the grafts either rejected or accepted, depending on the identity of the paired individuals, in a replicable and predictable manner. Fourteen transcriptomes were generated that spanned the auto- and allograft responses. Self grafts fuse completely in under three days, and the process appears to be controlled by relatively few genes. In contrast, nonself grafting results in a complete lack of fusion after three days, and appears to involve a broad downregulation of normal biological processes, rather than the mounting of an intense defensive response. View Full-Text
Keywords: allorecognition; histocompatibility; invertebrates; Porifera; RNA-Seq; self-nonself recognition; sponge allorecognition; histocompatibility; invertebrates; Porifera; RNA-Seq; self-nonself recognition; sponge
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Grice, L.F.; Degnan, B.M. Transcriptomic Profiling of the Allorecognition Response to Grafting in the Demosponge Amphimedon queenslandica. Mar. Drugs 2017, 15, 136.

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