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Mar. Drugs 2017, 15(3), 60; doi:10.3390/md15030060

Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics

College of Pharmacy, Chung-Ang University, Seoul 06974, Korea
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Academic Editors: Hitoshi Sashiwa and David Harding
Received: 26 January 2017 / Revised: 21 February 2017 / Accepted: 24 February 2017 / Published: 1 March 2017
(This article belongs to the Special Issue Advances in Marine Chitin and Chitosan II, 2017)
View Full-Text   |   Download PDF [1486 KB, uploaded 1 March 2017]   |  

Abstract

Chitosan has been widely used as a key biomaterial for the development of drug delivery systems intended to be administered via oral and parenteral routes. In particular, chitosan-based microparticles are the most frequently employed delivery system, along with specialized systems such as hydrogels, nanoparticles and thin films. Based on the progress made in chitosan-based drug delivery systems, the usefulness of chitosan has further expanded to anti-cancer chemoembolization, tissue engineering, and stem cell research. For instance, chitosan has been used to develop embolic materials designed to efficiently occlude the blood vessels by which the oxygen and nutrients are supplied. Indeed, it has been reported to be a promising embolic material. For better anti-cancer effect, embolic materials that can locally release anti-cancer drugs were proposed. In addition, a complex of radioactive materials and chitosan to be locally injected into the liver has been investigated as an efficient therapeutic tool for hepatocellular carcinoma. In line with this, a number of attempts have been explored to use chitosan-based carriers for the delivery of various agents, especially to the site of interest. Thus, in this work, studies where chitosan-based drug delivery systems have successfully been used for local delivery will be presented along with future perspectives. View Full-Text
Keywords: chitosan; local delivery; anti-cancer drugs; medical device chitosan; local delivery; anti-cancer drugs; medical device
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Hong, S.-C.; Yoo, S.-Y.; Kim, H.; Lee, J. Chitosan-Based Multifunctional Platforms for Local Delivery of Therapeutics. Mar. Drugs 2017, 15, 60.

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