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Mar. Drugs 2017, 15(11), 363; doi:10.3390/md15110363

Aspersymmetide A, a New Centrosymmetric Cyclohexapeptide from the Marine-Derived Fungus Aspergillus versicolor

1
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266200, China
3
State Key Laboratory for Marine Corrosion and Protection, Luoyang Ship Material Research (LSMRI), Qingdao 266061, China
4
Syngenta, Jealott’s Hill International Research Centre, Bracknell RG42 6EY, Berkshire, UK
5
Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China
*
Authors to whom correspondence should be addressed.
Received: 10 October 2017 / Revised: 31 October 2017 / Accepted: 13 November 2017 / Published: 22 November 2017
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Abstract

A new centrosymmetric cyclohexapeptide, aspersymmetide A (1), together with a known peptide, asperphenamate (2), was isolated from the fungus Aspergillus versicolor isolated from a gorgonian coral Carijoa sp., collected from the South China Sea. The chemical structure of 1 was elucidated by analyzing its NMR spectroscopy and MS spectrometry data, and the absolute configurations of the amino acids of 1 were determined by Marfey’s method and UPLC-MS analysis of the hydrolysate. Aspersymmetide A (1) represents the first example of marine-derived centrosymmetric cyclohexapeptide. Moreover, 1 exhibited weak cytotoxicity against NCI-H292 and A431 cell lines at the concentration of 10 μM. View Full-Text
Keywords: gorgonian-derived fungus; Carijoa sp.; Aspergillus versicolor; centrosymmetric cyclohexapeptide; cytotoxicity gorgonian-derived fungus; Carijoa sp.; Aspergillus versicolor; centrosymmetric cyclohexapeptide; cytotoxicity
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MDPI and ACS Style

Hou, X.-M.; Zhang, Y.-H.; Hai, Y.; Zheng, J.-Y.; Gu, Y.-C.; Wang, C.-Y.; Shao, C.-L. Aspersymmetide A, a New Centrosymmetric Cyclohexapeptide from the Marine-Derived Fungus Aspergillus versicolor. Mar. Drugs 2017, 15, 363.

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