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Mar. Drugs 2017, 15(1), 11; doi:10.3390/md15010011

Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)

1,2,†
,
3,4,5,†
,
6,7
and
1,8,9,10,11,*
1
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
2
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
3
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
4
Research Center for Industry of Human Ecology, Research Center for Chinese Herbal Medicine, and Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
5
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
6
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
7
Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi 613, Taiwan
8
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
9
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
10
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
11
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 20 November 2016 / Revised: 11 December 2016 / Accepted: 28 December 2016 / Published: 6 January 2017
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Abstract

Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D–J (17), with a 1,4-quinone moiety, were discovered from the gorgonian coral Pinnigorgia sp. In this study, the structures of secosterols 17 were revealed by spectroscopic analysis. Bioactivity study showed that secosterol 1 treatment inhibited cell viability in a hepatic stellate cell line, HSC-T6, with an IC50 value of 3.93 μM; and secosterols 2, 5, and 7 reduced elastase enzyme release, and 3, 5, and 7 decreased the production of superoxide anions from human neutrophils. View Full-Text
Keywords: 9,11-secosterol; gorgonian; Pinnigorgia; cytotoxicity; hepatic stellate cell line (HSC-T6); anti-inflammatory; superoxide anion; elastase 9,11-secosterol; gorgonian; Pinnigorgia; cytotoxicity; hepatic stellate cell line (HSC-T6); anti-inflammatory; superoxide anion; elastase
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Chang, Y.-C.; Hwang, T.-L.; Kuo, L.-M.; Sung, P.-J. Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae). Mar. Drugs 2017, 15, 11.

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