Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)
National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Research Center for Industry of Human Ecology, Research Center for Chinese Herbal Medicine, and Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi 613, Taiwan
Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944, Taiwan
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Orazio Taglialatela-Scafati
Received: 20 November 2016 / Revised: 11 December 2016 / Accepted: 28 December 2016 / Published: 6 January 2017
Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D–J (1
), with a 1,4-quinone moiety, were discovered from the gorgonian coral Pinnigorgia
sp. In this study, the structures of secosterols 1
were revealed by spectroscopic analysis. Bioactivity study showed that secosterol 1
treatment inhibited cell viability in a hepatic stellate cell line, HSC-T6, with an IC50
value of 3.93 μM; and secosterols 2
, and 7
reduced elastase enzyme release, and 3
, and 7
decreased the production of superoxide anions from human neutrophils.
This is an open access article distributed under the Creative Commons Attribution License
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Scifeed alert for new publications
Never miss any articles
matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
Define your Scifeed now
Share & Cite This Article
MDPI and ACS Style
Chang, Y.-C.; Hwang, T.-L.; Kuo, L.-M.; Sung, P.-J. Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae). Mar. Drugs 2017, 15, 11.
Chang Y-C, Hwang T-L, Kuo L-M, Sung P-J. Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae). Marine Drugs. 2017; 15(1):11.
Chang, Yu-Chia; Hwang, Tsong-Long; Kuo, Liang-Mou; Sung, Ping-Jyun. 2017. "Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)." Mar. Drugs 15, no. 1: 11.
Show more citation formats
Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
[Return to top]
For more information on the journal statistics, click here
Multiple requests from the same IP address are counted as one view.