Trichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii Bloom
AbstractIn an effort to isolate and characterize bioactive secondary metabolites from Trichodesmium thiebautii blooms, collected cyanobacteria biomass was subjected to bioassay-guided extraction and fractionation using the human colon cancer cell line HCT-116, resulting in the isolation and subsequent structure characterization of a linear polyketide trichophycin A (1). The planar structure of 1 was completed using 1D and 2D NMR spectroscopy and high-resolution electrospray ionization mass spectrometry (HRESIMS). Trichophycin A was moderately toxic against the murine neuroblastoma cell line Neuro-2A (EC50: 6.5 μM) and HCT-116 cells (EC50: 11.7 μM). Trichophycin A was significantly more cytotoxic than the previously isolated polyketides trichotoxin A and trichotoxin B. These cytotoxicity observations suggest that toxicity may be related to the polyol character of these polyketide compounds. View Full-Text
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Bertin, M.J.; Wahome, P.G.; Zimba, P.V.; He, H.; Moeller, P.D.R. Trichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii Bloom. Mar. Drugs 2017, 15, 10.
Bertin MJ, Wahome PG, Zimba PV, He H, Moeller PDR. Trichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii Bloom. Marine Drugs. 2017; 15(1):10.Chicago/Turabian Style
Bertin, Matthew J.; Wahome, Paul G.; Zimba, Paul V.; He, Haiyin; Moeller, Peter D.R. 2017. "Trichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii Bloom." Mar. Drugs 15, no. 1: 10.
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