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Mar. Drugs 2017, 15(1), 10; doi:10.3390/md15010010

Trichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii Bloom

1
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 7 Greenhouse Road, Kingston, RI 02881, USA
2
Biosortia Pharmaceuticals, Hollings Marine Laboratory, 331 Fort Johnson Road, Charleston, SC 29412, USA
3
Department of Life Sciences, Texas A&M Corpus Christi, 6300 Ocean Drive, Corpus Christi, TX 78412, USA
4
Emerging Toxins Program, National Ocean Service/NOAA, Hollings Marine Laboratory, 331 Fort Johnson Road, Charleston, SC 29412, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 13 December 2016 / Revised: 28 December 2016 / Accepted: 30 December 2016 / Published: 6 January 2017
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Abstract

In an effort to isolate and characterize bioactive secondary metabolites from Trichodesmium thiebautii blooms, collected cyanobacteria biomass was subjected to bioassay-guided extraction and fractionation using the human colon cancer cell line HCT-116, resulting in the isolation and subsequent structure characterization of a linear polyketide trichophycin A (1). The planar structure of 1 was completed using 1D and 2D NMR spectroscopy and high-resolution electrospray ionization mass spectrometry (HRESIMS). Trichophycin A was moderately toxic against the murine neuroblastoma cell line Neuro-2A (EC50: 6.5 μM) and HCT-116 cells (EC50: 11.7 μM). Trichophycin A was significantly more cytotoxic than the previously isolated polyketides trichotoxin A and trichotoxin B. These cytotoxicity observations suggest that toxicity may be related to the polyol character of these polyketide compounds. View Full-Text
Keywords: Trichodesmium thiebautii blooms; polyketide; polyol; secondary metabolite Trichodesmium thiebautii blooms; polyketide; polyol; secondary metabolite
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MDPI and ACS Style

Bertin, M.J.; Wahome, P.G.; Zimba, P.V.; He, H.; Moeller, P.D.R. Trichophycin A, a Cytotoxic Linear Polyketide Isolated from a Trichodesmium thiebautii Bloom. Mar. Drugs 2017, 15, 10.

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