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Mar. Drugs 2016, 14(7), 132; doi:10.3390/md14070132

Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum

1
The United Graduate School of Agricultural Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
2
Faculty of Science and Technology, Valaya Alongkorn Rajabhat University under Royal Patronage, Pathumtani 13138, Thailand
3
Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
*
Author to whom correspondence should be addressed.
Academic Editor: Vassilios Roussis
Received: 25 May 2016 / Revised: 5 July 2016 / Accepted: 6 July 2016 / Published: 15 July 2016
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Abstract

Six new chamigrane sesquiterpenes, merulinols A‒F (16), and four known metabolites (710) were isolated from the culture of the basidiomycetous fungus XG8D, a mangrove-derived endophyte. Their structures were elucidated mainly by 1D and 2D NMR, while the structures of 1 and 2 were further confirmed by single-crystal X-ray diffraction analysis. The in vitro cytotoxicity of all compounds was evaluated against three human cancer cell lines, MCF-7, Hep-G2, and KATO-3. Compounds 3 and 4 selectively displayed cytotoxicity against KATO-3 cells with IC50 values of 35.0 and 25.3 μM, respectively. View Full-Text
Keywords: chamigrane; sesquiterpene; endophytic fungus; cytotoxic chamigrane; sesquiterpene; endophytic fungus; cytotoxic
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Choodej, S.; Teerawatananond, T.; Mitsunaga, T.; Pudhom, K. Chamigrane Sesquiterpenes from a Basidiomycetous Endophytic Fungus XG8D Associated with Thai Mangrove Xylocarpus granatum. Mar. Drugs 2016, 14, 132.

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